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IFNG — TG
Text-mined interactions from Literome
Kung et al., Clin Exp Immunol 1992
(Thyroiditis) :
We have previously demonstrated that
IFN-gamma suppressed thyroid stimulating hormone ( TSH ) -stimulated
thyroglobulin (TG) synthesis in human thyrocytes through inhibition of TG gene transcription
Ashizawa et al., J Clin Endocrinol Metab 1989
:
We have previously demonstrated that
interferon-gamma (IFN-gamma) induced HLA-DR antigen and also
inhibited thyrotropin ( TSH ) -induced triiodothyronine ( T3 ) and
thyroglobulin (Tg) secretion from cultured human thyrocytes
Rasmussen et al., J Endocrinol 1994
:
In the present study, TNF-alpha, TNF-beta and
IFN-gamma all
inhibited thyroglobulin (Tg) and cAMP production from cultured human thyroid cells
Tang et al., Endocrinology 1995
:
In the present study, we used FRTL5 cells, a cultured rat thyroid follicular cell line, to examine the
effects of
IFN-gamma and TNF-alpha on type I 5'-deiodinase ( 5'D-I ) activity and 5'D-I, thyroid peroxidase (TPO) and
thyroglobulin (Tg) gene expression
Resetkova et al., Clin Invest Med 1993
(Graves Disease...) :
We have investigated the in vitro
effects of interleukin-1-beta (IL-1-beta), interleukin-2 (IL-2), tumor necrosis factor-alpha (TNF-alpha), and
interferon-gamma (IFN-gamma) on the induction of anti-thyroperoxidase ( anti-TPO ),
anti-thyroglobulin ( anti-Tg ), and IgG secreting cells ( SC ) by cultures of pokeweed mitogen ( PWM ) -stimulated peripheral blood mononuclear cells ( PBMC ) obtained from patients with Hashimoto 's thyroiditis ( HT ), Graves ' disease ( GD ), and controls ( C )
Kung et al., J Mol Endocrinol 1998
:
We have shown previously that
IFNgamma inhibited
thyroglobulin (Tg) gene transcription, and that its action was mediated by an increase in intracellular calcium and inositol phosphates