Gene interactions and pathways from curated databases and text-mining

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DUSP5 — TP53

Text-mined interactions from Literome

Ueda et al., Oncogene 2003 : Transcription of DUSP5 was also remarkably activated by endogenous p53 in response to DNA damage in colon-cancer cells ( p53+/+ ) that contained wild-type p53, but not in p53-/- cells
Shang et al., Oncogene 2010 (Neuroblastoma) : In contrast, DUSP26 overexpression in the SK-N-SH cell line inhibited doxorubicin induced p53 phosphorylation at Ser20 and Ser37, p21, Puma, Bax expression and apoptosis