◀ Back to TP53
COP — TP53
Text-mined interactions from Literome
Dornan et al., Nature 2004
:
Depletion of
COP1 by short interfering RNA ( siRNA )
stabilizes p53 and arrests cells in the G1 phase of the cell cycle
Dornan et al., Cancer Res 2004
(Adenocarcinoma...) :
COP1 , the negative
regulator of
p53 , is overexpressed in breast and ovarian adenocarcinomas
Yoneda-Kato et al., EMBO J 2005
(Leukemia, Myeloid) :
Myeloid leukemia factor 1
regulates p53 by suppressing
COP1 via COP9 signalosome subunit 3
Dulloo et al., J Biol Chem 2005
(Lung Neoplasms) :
The
tumor suppressor p53 regulates its own stability by transcriptionally activating Mdm2, Pirh2, and
COP1 , which target p53 for degradation
Lee et al., Cancer Res 2010
(Carcinoma, Hepatocellular...) :
The ubiquitination modulator
COP1 regulates
p53 activity by ubiquitination and it is frequently overexpressed in human HCC
Wei et al., J Clin Invest 2011
(Neoplasms) :
These findings challenge the view that
COP1 regulates
p53 stability and call into question the wisdom of developing COP1 inhibitors as potential anticancer agents