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IFNG — PTPN11
Pathways - manually collected, often from reviews:
-
OpenBEL Selventa BEL large corpus:
Complex of PTPN11-STAT1
→
IFNG
(increases)
Wu et al., J Biol Chem 2002
Evidence: SHP-2 and Stat1 nuclear localization and their association in response to either epidermal growth factor or interferon-gamma (IFNgamma) were confirmed by immunofluorescent staining and affinity precipitation assays.
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NCI Pathway Database SHP2 signaling:
IFN-gamma/IFN-gammaR/JAK1/JAK1/JAK2/JAK2 complex (IFNGR1-JAK1-JAK2-IFNG)
→
SHP2 (PTPN11)
(translocation, activates)
Wu et al., J Biol Chem 2002
Evidence: assay
-
NCI Pathway Database IFN-gamma pathway:
IFN-gamma (dimer) complex (IFNG)
→
SHP2 (PTPN11)
(modification, collaborate)
You et al., Mol Cell Biol 1999, Krause et al., Mol Cell Proteomics 2002, Igarashi et al., J Biol Chem 1994, Marsters et al., Proc Natl Acad Sci U S A 1995, Greenlund et al., EMBO J 1994, Müller et al., Nature 1993
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database IFN-gamma pathway:
IFN-gamma/IFN-gammaR/JAK1/JAK1/JAK2/JAK2 complex (IFNGR1-JAK1-JAK2-IFNG)
→
SHP2 (PTPN11)
(translocation, activates)
Wu et al., J Biol Chem 2002
Evidence: assay
-
Reactome Reaction:
IFNG
→
PTPN11
(reaction)
Text-mined interactions from Literome
Park et al., J Immunol 2005
:
In the
presence of
IFN-gamma , TGF-beta1 rapidly induced in Th cells the synthesis of the PTP Shp-1, but did not induce
Shp-2 or several members of the suppressor of cytokine signaling family of Jak-Stat inhibitors
Abschuetz et al., Cell Tissue Res 2006
(Glioma) :
Moreover, stimulation with LPS and/or
IFN-gamma resulted in a decreased expression of the viral replicative and cytotoxic protein
NS1
Su et al., Biochem Biophys Res Commun 2007
(Urinary Bladder Neoplasms) :
Therefore, the suppression of
IFN-gamma signaling in HER-2/neu overexpressing bladder cancer cells might be
due to
SHP-2 upregulation