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EGF — SP1

Text-mined interactions from Literome

Chupreta et al., Am J Physiol Cell Physiol 2000 : Erk is capable of phosphorylating other mitogen-inducible transcription factors, e.g., Elk and Sap, suggesting that Erk may also mediate EGF dependent phosphorylation of Sp1 ... Phosphoamino acid analysis of in vivo radiolabeled Sp1 demonstrated that the kinase phosphorylates Sp1 on Ser and Thr in response to EGF ... Therefore, most EGF stimulated Sp1 kinase activity is Mek 1 dependent and distinct from Erk
Zheng et al., J Biol Chem 2001 (MAP Kinase Signaling System) : In summary, EGF stimulation of apoA-I expression is mediated solely by the Ras-MAP kinase cascade and enhanced activity of this pathway requires Sp1 with an intact phosphorylation site at Thr ( 266 )
Keating et al., Oncogene 2001 : On the other hand full-length ATM cDNA increased the basal level of Sp1 binding in A-T cells, and in response to EGF Sp1 binding decreased, confirming that this is an ATM dependent process
Halpern et al., J Pediatr Gastroenterol Nutr 2003 (Disease Models, Animal...) : These data suggest that EGF may reduce NEC via increased interleukin-10 and decreased interleukin-18 and that EGF mediated up-regulation of Sp1 may account for the increased interleukin-10
Chang et al., Prostaglandins Other Lipid Mediat 2003 : The direct and cooperative interaction between c-Jun and Sp1 induced by EGF or PMA activates the expression of the human 12(S)-lipoxygenase gene
Chen et al., J Biol Chem 2007 : This study investigated in detail the molecular events incurred upon p300 whereby EGF caused an enhanced interaction between p300 and Sp1
Bermudez et al., Growth Factors 2008 (Ovarian Neoplasms) : Pyk2/ERK 1/2 mediate Sp1- and c-Myc dependent induction of telomerase activity by epidermal growth factor
Ikari et al., Biochem Biophys Res Commun 2009 : EGF increased Sp1 expression within 1h, which was inhibited by U0126 ... We suggest that EGF activates a MEK/ERK pathway and increases Sp1 expression, resulting in an elevation of claudin-4 expression
Huang et al., Cell Mol Life Sci 2010 : Involvement of aryl hydrocarbon receptor nuclear translocator in EGF induced c-Jun/Sp1 mediated gene expression ... EGF induced promoter activity and the mRNA level of 12(S)-lipoxygenase as well as the association between c-Jun and Sp1 were reduced by ARNT knockdown ... Moreover, ARNT knockdown also inhibited other EGF induced c-Jun/Sp1 mediated gene expression, such as p21 ( WAF1/CIP1 )
Taniuchi et al., Biochem Biophys Res Commun 1997 (Stomach Neoplasms) : Sp1 binds to the same DNA element and transactivates gastrin promoter activity, whereas ZBP-89 competes for Sp1 binding and prevents EGF induction
Mortensen et al., J Biol Chem 1997 : Okadaic acid, a phosphatase inhibitor, was synergistic with the effect of EGF on Sp1 protein levels suggesting that the loss of Sp1 was mediated by phosphorylation events ... Cycloheximide prevented the expected loss of Sp1 mediated by EGF and okadaic acid suggesting that the synthesis of a protease may mediate these events