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EGF — SLC22A3

Text-mined interactions from Literome

Morabito et al., Dev Biol 2001 : Using a quantitative in vitro collagen gel assay, we show that serum, FGF-1, -2, and -7, VEGF, and EGF stimulate epicardial EMT
Higgins et al., Kidney Int 2003 (Disease Progression...) : A sustained increase in fisp-12 mRNA level was observed during EMT induced by transforming growth factor-beta1 ( TGF-beta1 ) and epidermal growth factor (EGF)
Salamanca et al., J Soc Gynecol Investig 2004 : EGF+HC induced EMT ( mesenchymal shapes, reduced keratin, and production of collagenous extracellular matrix ), but the EMT response varied greatly among OSE from different women ... EGF+HC enhances growth but initiates EMT , which likely mimics a repair response
Lim et al., Int J Cancer 2007 : NGAL expression was downregulated in ovarian cancer cell lines undergoing epithelio-mesenchymal transition (EMT) induced by epidermal growth factor (EGF)
Lo et al., Cancer Res 2007 (Breast Neoplasms...) : In search of a downstream mediator that may account for EGF induced EMT , we focused on transcription repressors of E-cadherin, TWIST, SLUG, and Snail and found that cancer cells express high levels of TWIST and that EGF enhances its expression
Uttamsingh et al., Oncogene 2008 (Cell Transformation, Neoplastic) : Inhibition of MAPK, but not phosphoinositide-3 kinase (PI3K), abolished TGF-beta1 plus EGF induced EMT and downregulation of E-cadherin at mRNA and protein levels
Odero-Marah et al., Cell Res 2008 (Carcinoma...) : We observed that both epidermal growth factor (EGF) plus TGFbeta1 treatment and Snail overexpression induced EMT in ARCaP ( E ) and LNCaP cells, and EMT was associated with increased expression of RANKL protein
Lee et al., Clin Cancer Res 2008 (Carcinoma, Squamous Cell...) : alpha(5)beta(1) integrin signaling and extracellular matrix fibronectin can modulate EGF induced EMT
Colomiere et al., Br J Cancer 2009 (Ovarian Neoplasms) : The association between STAT3 activation and migratory phenotype of ovarian cancer cells was investigated by EGF induced epithelial-mesenchymal transition (EMT) in OVCA 433 and SKOV3 ovarian cancer cell lines
Cai et al., Cancer 2009 (Esophageal Neoplasms...) : The effects of maspin reintroduction on EGF induced EMT and cell growth characteristics were evaluated ... The introduction of maspin into EC109 cells was able to inhibit EGF induced EMT and altered cell growth characteristics, including the serum dependence, proliferative response to EGF stimulation, and colony formation ability in soft agar, indicating a conversion from a malignant phenotype to a benign phenotype
Hugo et al., BMC cancer 2009 (Breast Neoplasms) : EGF induces EMT in the breast cancer cell line PMC42-LA and the kinase inhibitor staurosporine ( ST ) induces EMT in embryonic neural epithelial cells, with F-actin de-bundling and disruption of cell-cell adhesion, via inhibition of aPKC ... This appeared fundamentally different to the EGF induced EMT , highlighting the multiple pathways which can regulate EMT
Vergara et al., Cancer Lett 2010 (Neoplasm Metastasis...) : In ovarian cancer EMT is induced by transforming growth factor-beta ( TGF-beta ), epidermal growth factor (EGF) , hepatocyte growth factor (HGF) and endothelin-1 (ET-1)
Ardura et al., J Am Soc Nephrol 2010 (Disease Models, Animal...) : TGF-beta1 and EGF stimulate EMT ... Moreover, inhibition of ERK1/2 blocked EMT induced by either PTHrP ( 1-36 ), TGF-beta1, EGF , or VEGF
Xu et al., Biochem Biophys Res Commun 2010 (Ovarian Neoplasms) : Taken together, our data demonstrate that TGFß and EGF signaling pathways synergistically induce EMT and render EOC cells a more invasive phenotype
Byles et al., Oncogene 2012 (Neoplasm Metastasis...) : We also found that SIRT1 has a physiologically relevant role in endogenous EMT induced by EGF signaling in prostate cancer cells
Cheng et al., PloS one 2012 (Cystadenocarcinoma, Serous...) : EGF induced EMT and invasiveness in serous borderline ovarian tumor cells : a possible step in the transition to low-grade serous carcinoma cells ?
Liu et al., Tumour Biol 2012 (Pancreatic Neoplasms) : We demonstrated that transforming growth factor-ß1 ( TGF-ß1 ) promoted epidermal growth factor (EGF) induced EMT in co-treated human pancreatic BxPC3 cells and that JDP2 overexpression reversed the EMT that was induced by co-treatment with TGF-ß1 and EGF ... These results suggest that EGF plays a principal role in EMT through its association with TGF-ß1 in human pancreatic BxPC3 cells and that JDP2 may be a molecular target for pancreatic carcinoma intervention
Davis et al., PloS one 2012 (Breast Neoplasms...) : Non stimulated, agonist stimulated and store operated Ca2+ influx in MDA-MB-468 breast cancer cells and the effect of EGF induced EMT on calcium entry ... In this study we show that EGF induced EMT in MDA-MB-468 breast cancer cells is associated with a reduction in agonist stimulated and store operated Ca ( 2+ ) influx, and that MDA-MB-468 cells prior to EMT induction have a high level of non stimulated Ca ( 2+ ) influx
Smith et al., Oral Oncol 2013 (Carcinoma, Squamous Cell...) : Epidermal growth factor (EGF) and transforming growth factorß ( TGFß ) promote EMT by regulating a distinct set of transcription factors, including Snail and Twist
Misra et al., PloS one 2012 (Neoplasms) : EGF ( Epidermal Growth Factor ) is a known inducer of EMT and growth of A431 cells in the absence of oxygen led to increased expression of EGFR ( EGF Receptor )
Zhang et al., J Biol Chem 2013 (Neoplasm Metastasis...) : Using experimental models of PCa metastasis, we demonstrated that EGF could induce robust epithelial-mesenchymal transition (EMT) and increase invasiveness ... This study elucidated a novel molecular mechanism for EGF regulation of EMT and invasiveness in PCa cells, indicating that blockade of EGF signaling could be beneficial in preventing and retarding PCa metastasis at early stages
Lei et al., PloS one 2012 (Uterine Cervical Neoplasms) : The epithelial-mesenchymal transition (EMT) induced by EGF promotes cervical cancer progression ; however, the mechanisms underlying the EGF induced EMT remain unclear ... In this study, we reported that miR155 overexpression suppressed EGF induced EMT , decreased migration/invasion capacities, inhibited cell proliferation and increased the chemo-sensitivity to DDP in human Caski cervical cancer cells ... These data suggest that miR155 negatively regulates EGF induced EMT
Davis et al., Cancer cell international 2013 : However, EGF induced EMT was associated with significant alterations in mRNA levels of specific ER calcium channels and pumps, including ( sarco ) -endoplasmic reticulum calcium ATPases ( SERCAs ), and inositol 1,4,5-trisphosphate receptor ( IP3R ) and ryanodine receptor ( RYR ) calcium channel isoforms ... These findings indicate that EGF induced EMT in breast cancer cells may be associated with major alterations in ER calcium homeostasis