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JUN — PLK3
Text-mined interactions from Literome
Wang et al., J Biol Chem 2007
:
Stress induced
c-Jun activation
mediated by
Polo-like kinase 3 in corneal epithelial cells ... In the present study, we report that UV irradiation activated
Plk3 and that Plk3 interacts with
AP-1 and c-Jun, which appears to be important to
mediate corneal epithelial cell apoptosis after UV irradiation ... Our results thus provide for the first time that
Plk3 mediates UV irradiation
induced c-Jun activation by phosphorylating c-Jun, suggesting that Plk3 plays an important role in mediating programmed cell death of corneal epithelial cells after UV irradiation
Wang et al., J Biol Chem 2008
(Anoxia) :
The
effect of hypoxia/reoxygenation stress induced
Plk3 activation on increased
c-Jun phosphorylation and apoptosis was also mimicked by exposure of cells to CoCl ( 2 ) ... Our results provide a new mechanism indicating that hypoxia/reoxygenation induces
Plk3 activation instead of the JNK effect to directly phosphorylate and
activate c-Jun , subsequently contributing to apoptosis in HCE cells
Wang et al., Invest Ophthalmol Vis Sci 2011
:
Hyperosmotic stress induced
c-Jun phosphorylation was
enhanced by overexpression of constitutively positive
Plk3 mutants and suppressed by the knockdown of Plk3 mRNA with Plk3-specific siRNA