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CTNNB1 — FGF8
Text-mined interactions from Literome
Treichel et al., Genes Dev 2003
:
We present evidence that mBtd is required during early limb development to maintain, but not to initiate
Wnt/beta-catenin dependent
FGF , Shh, and BMP mediated signaling
Maegawa et al., Development 2006
:
By contrast, when
FGF signaling is inhibited,
beta-catenin did not
induce goosecoid and chordin, repress bmp4 expression or induce a dorsal axis ... These results demonstrate that
FGF signaling is
necessary for
beta-catenin induction of the zebrafish organizer
Katoh et al., Cancer Biol Ther 2007
(Helicobacter Infections...) :
WNT-beta-catenin-TCF/LEF signaling
induces upregulation of MYC, CCND1, WISP1,
FGF20 , JAG1 and DKK1 genes
Ambrosetti et al., Mol Cell Biol 2008
:
FGF did not significantly
affect the activation of
beta-catenin , although it reduced both the expression of TCF/LEF factors and their induction by Wnt. Microarray analysis using osteoblasts treated with Wnt3a and FGF alone or in combination showed that about 70 % of the genes induced by Wnt3a were downregulated by combined FGF treatment
Miyagawa et al., Development 2009
:
The current data also suggest that
Wnt/beta-catenin regulates
Fgf8 expression via Lef/Tcf binding sites in a 3 ' conserved enhancer
Villacorte et al., Biochem Biophys Res Commun 2010
:
We also demonstrated that
Wnt/beta-catenin signaling in the ectoderm can positively
regulate Fgf8 possibly antagonizing the epithelial derived Bmp signaling