◀ Back to NFKB1
NFKB1 — USP11
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Yamaguchi et al., J Biol Chem 2007
:
However, down-regulation of
USP11 dramatically
enhances NF-kappaB activity in response to tumor necrosis factor-alpha, indicating that IKKalpha does not require activation of NF-kappaB
Sun et al., Cell Signal 2010
:
USP11 negatively
regulates TNFalpha induced
NF-kappaB activation by targeting on IkappaBalpha ... These data demonstrate that
USP11 plays an important role in the downregulation of TNFalpha mediated
NF-kappaB activation through modulating IkappaBalpha stability ... In addition, overexpression of a catalytically inactive
USP11 mutant partially
inhibits TNFalpha- and IKKbeta induced
NF-kappaB activation, suggesting that USP11 also exerts a non-catalytic function in its negative regulation of TNFalpha mediated NF-kappaB activation