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HDC — IL1A

Text-mined interactions from Literome

Yamaguchi et al., Br J Pharmacol 2000 (Inflammation) : Because interleukin-1 (IL-1) is a typical pyrogen and a strong inducer of HDC , we examined whether aminoBPs induce inflammatory reactions in mice deficient in genes for both IL-1alpha and IL-1beta ( IL-1-KO mice )
Endo et al., Immunol Lett 1992 : IL-1 alpha , IL-1 beta, TNF alpha and TNF beta induced HDC and ODC, as does LPS
Endo et al., Br J Pharmacol 1992 (Drug-Induced Liver Injury) : 6. The induction of HDC in the liver by LPS, IL-1 or TNF was not suppressed by GalN and, at high doses, the response to LPS was enhanced
Wu et al., Int Immunopharmacol 2004 : To examine the contribution of mast cells to HDC induction in mice given LPS or IL-1, we examined the effects of LPS and IL-1 on HDC activity and/or histamine content in various organs ( liver, lung, spleen or bone marrow ) in mast cell-deficient mice ( W/Wv ), their normal littermates ( +/+ ) and BALB/c mice deficient in IL-1alpha, IL-1beta and tumor necrosis factor (TNF)-alpha ( IL-1alpha beta/TNFalphaKO mice ) ... These results suggest that ( i ) in liver, lung and spleen, either the major cells supplying histamine via HDC induction in response to LPS and IL-1 are not mast cells, or mast cells are not a prerequisite for the induction of HDC ; ( ii ) the cells in which HDC is induced by LPS and IL-1 are similar or identical in a given organ ; and ( iii ) neither IL-1 nor TNF-alpha is a prerequisite for the induction of HDC by LPS
Deng et al., Toxicol Appl Pharmacol 2006 : We reported previously that in mice, ( i ) the inflammatory actions of N-BPs depend on IL-1, ( ii ) N-BP pretreatment augments both LPS stimulated IL-1 production and HDC induction , and ( iii ) the co-administration of clodronate ( a non-N-BP ) with an N-BP inhibits the latter 's inflammatory actions ( including HDC induction )
Okamoto et al., Immunology 1990 : Alpha-fluoromethylhistidine, a suicide inhibitor of HDC , attenuated , in a dose dependent manner, both spontaneous and LPS stimulated IL-1 synthesis by macrophages
Endo et al., Br J Pharmacol 1995 : 3. In macrophage depleted mice, the induction of HDC by LPS, IL-1 alpha or TNF-alpha was not impaired in the liver, and was potentiated in the lung and bone marrow
Kikuchi et al., Biochem Pharmacol 1997 : These results suggest that IL-1alpha induces HDC activity or its enzyme protein through the formation of short lived HDC mRNA molecules