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IL8 — RNF19A

Text-mined interactions from Literome

Suzuki et al., FEBS Lett 2000 (Arthritis, Rheumatoid) : We examined the role of p38 mitogen activated protein ( MAP ) kinase in the tumor necrosis factor alpha (TNF-alpha)- or interleukin-1beta (IL-1beta) induced production of interleukin-6 (IL-6) and interleukin-8 (IL-8) in fresh rheumatoid synovial fibroblast ( RSF ) cultures concomitantly with the induction of p38 MAP kinase activity
Refsnes et al., Toxicology 2001 : Inhibition of the MAP kinase p38 by SB202190 partially reduced the IL-8 response to NaF, whereas a reduction in ERK activity by PD98059 led to an increased response
Li et al., Am J Physiol Lung Cell Mol Physiol 2002 (MAP Kinase Signaling System) : Recent studies indicate that maximal IL-8 protein expression requires activation of NF-kappaB as well as activation of the MAP kinases ERK, JNK, and p38
Parhar et al., Immunology 2003 : The p38 mitogen activated protein kinase regulates interleukin-1beta induced IL-8 expression via an effect on the IL-8 promoter in intestinal epithelial cells
Li et al., Am J Physiol Lung Cell Mol Physiol 2003 (MAP Kinase Signaling System) : Inhibition of p38 and ERK1/2 did not affect stretch induced IL-8 production
Ribeiro et al., Mediators Inflamm 2003 : The p38 mitogen activated protein kinase inhibitor SB 203580 inhibits the IL-8 mRNA expression and the release of protein from neutrophils
Merz et al., J Immunol 2003 (Hypertrophy...) : In conclusion, IL-8 and GROalpha induce articular chondrocyte hypertrophy and calcification through p38 and TG2
Ryu et al., Infect Immun 2004 (Trichomonas Vaginitis) : Furthermore, an NF-kappaB inhibitor ( pyrrolidine dithiocarbamate ), a mitogen activated protein ( MAP ) kinase ( MEK ) inhibitor ( PD98059 ), and a p38 MAP kinase inhibitor ( SB203580 ) significantly suppressed IL-8 synthesis in neutrophils
Brunius et al., Regul Pept 2005 : The specific p38 mitogen activated protein kinase ( MAPK ) inhibitor SB 203580 reduced IL-8 production stimulated by the combination of BK and IL-1beta as well as the IL-1beta stimulated IL-8 production
Shinkai et al., Am J Physiol Lung Cell Mol Physiol 2006 : The p38 MAP kinase inhibitor, SB-203580 increased ERK phosphorylation and IL-8 secretion
Dobreva et al., J Biol Chem 2006 (Atherosclerosis) : Interleukin-8 secretion by fibroblasts induced by low density lipoproteins is p38 MAPK dependent and leads to cell spreading and wound closure
Lee et al., Cytokine 2006 (Tooth Migration) : Roles of p38 and ERK MAP kinases in IL-8 expression in TNF-alpha- and dexamethasone stimulated human periodontal ligament cells
Lewthwaite et al., Int Immunopharmacol 2007 (Inflammation) : Selective inhibitors of p38 ( mapk ) ( SB203580 ) or of MEK1/2, the direct upstream activator of ERK1/2 ( PD98059 ), reduced the synthesis of IL-1beta, TNFalpha, IL-6 and IL-8 induced by either the chaperonins or LPS
Chandru et al., Gene 2007 : Pharmacological inhibitors of ERK and p38 but not JNK partly inhibited S1-P induction of IL-8 mRNA levels
Ivison et al., J Immunol 2007 : Finally, involvement of PKD in the p38 mediated IL-8 response to flagellin was confirmed by small hairpin RNA mediated gene silencing
Choi et al., J Cell Biochem 2007 : Transcriptional regulation of IL-8 by iron chelator in human epithelial cells is independent from NF-kappaB but involves ERK1/2- and p38 kinase dependent activation of AP-1
Grund et al., Mol Pharmacol 2008 (Endometriosis...) : Interestingly, MEK, p38 , and IKK inhibitors block TNF-alpha induced IL-8 , IL-6, and GM-CSF secretion and 12z invasion, whereas the PI3K inhibitors do not
Tahan et al., Clin Exp Allergy 2008 : TNF-alpha induced IL-8 release was suppressed by an NF-kappaB inhibitor but not by MEK or p38 MAPK inhibitors
Harrison et al., Infect Immun 2008 : FlaA induced IL-8 production in T84 cells was inhibited by the p38 inhibitor in combination with either the JNK or ERK inhibitors
Allison et al., J Immunol 2009 : Pharmacological inhibition of p38 and ERK activity significantly reduced IL-8 production in response to H. pylori, further emphasizing the importance of MAPKs in innate immune responses to the pathogen
Jandhyala et al., Infect Immun 2010 (Escherichia coli Infections) : Inhibition of MAPK interacting kinase 1 suggests that p38 signaling affects the posttranscriptional regulation of interleukin-8 protein expression induced by flagellin
Bhattacharyya et al., Am J Physiol Lung Cell Mol Physiol 2011 (Cystic Fibrosis...) : However, we find that inhibition of ERK1/2 or p38 leads to suppression of the effect of JNK-2 inhibition on IL-8 mRNA stability
Kloesch et al., Rheumatol Int 2012 : Inhibitors of p38 and ERK1/2 MAPkinase and hydrogen sulphide block constitutive and IL-1ß induced IL-6 and IL-8 expression in the human chondrocyte cell line C-28/I2
Sunaga et al., Int J Cancer 2012 (Carcinoma, Non-Small-Cell Lung...) : In KRAS mutant cells, the MEK inhibitor markedly decreased IL-8 expression, while the p38 inhibitor increased IL-8 expression
Wang et al., Inflamm Res 2012 : The p38 inhibitor SB203580 and the STAT1 inhibitor EGCG blocked CM-induced IL-8 production at both early and late time periods
Gon et al., Biochem Biophys Res Commun 1998 : The specific p38 MAP kinase inhibitor SB 203580 inhibited cooling and rewarming induced IL-8 expression, indicating that cooling and rewarming induced IL-8 expression in BEC was mediated through p38 MAP kinase dependent pathway