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CD8A — TLR8

Text-mined interactions from Literome

Kiniwa et al., Clin Cancer Res 2007 (Prostatic Neoplasms) : Our study shows that like CD4 ( + ) CD25 ( + ) Treg cells, CD8 ( + ) Foxp3 ( + ) Treg cells present in prostate tumor derived TILs suppress immune responses and that their suppressive function can be regulated by TLR8 ligands, raising the possibility that the manipulation of Treg cell function by TLR8 ligands could improve the efficacy of immunotherapy for prostate cancer patients
Heidegger et al., J Immunol 2013 (Salmonella Infections) : We further show that this downregulation is dependent on TLR signaling, and that the TLR activated naive CD8 ( + ) T cells are blocked from entering GALT