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IL2 — LTA

Text-mined interactions from Literome

Reddy et al., Int Immunol 2001 : IL-2 induced tumor necrosis factor (TNF)-beta expression : further analysis in the IL-2 knockout model, and comparison with TNF-alpha, lymphotoxin-beta, TNFR1 and TNFR2 modulation
Plitnick et al., Clin Diagn Lab Immunol 2001 : Flow cytometric analysis revealed that IL-2 binding to T cells is inhibited in the presence of purified LTA but not LTA plus anti-LTA monoclonal antibody
Xu et al., Biochem Biophys Res Commun 2001 : The p38 MAPK pathway is involved in the IL-2 induction of TNF-beta gene via the EBS element ... Furthermore, using kinase inhibitors, we revealed that p38 MAP kinase is involved in the formation of -130EBS-protein complex and the subsequent transcriptional activation of TNF-beta gene in response to IL-2 stimulation ... Taken together, our results suggested that the complicated IL-2 induction of TNF-beta gene expression requires not only the activation of JAK-STAT pathway on the -200GAS element, but also the cooperation of another signal pathway on the -130EBS element
Morath et al., Infect Immun 2002 : After purification, the commercial LTA from Bacillus subtilis and S. pyogenes but not LTA from S. aureus induced the release of tumor necrosis factor alpha, interleukin 1 beta (IL-1beta), IL-6, and IL-10 in human blood
Limb et al., Immunology 1992 : The mean fluorescence intensity ( MFI ) of monocyte CD11a was enhanced by interleukin-2 (IL-2) , TNF-alpha and TNF-beta, and that of CD11b, CD11c and CD18 was increased by IL-2, IL-4, TNF-alpha and TNF-beta
Weil et al., Mol Cell Biol 1990 : As a consequence, there was a delay in the appearance of cytoplasmic messengers after the transcriptional induction of TNF beta by IL-2
Jana et al., Immunology 2009 : Induction of lymphotoxin-alpha by interleukin-12 p40 homodimer, the so-called biologically inactive molecule, but not IL-12 p70
Som et al., Clinical and vaccine immunology : CVI 2012 (Disease Models, Animal...) : Anti-inflammatory SMAMPs prevented the induction of tumor necrosis factor (TNF), interleukin 6 (IL-6), and IL-10 in response to S. aureus or LTA , but no other TLR2 ligands
Weil et al., Oncogene Res 1988 : This led us to investigate the regulation by IL2 of TNF-alpha, TNF-beta , and interferon-gamma (IFN-gamma) mRNA
Palladino et al., Ciba Found Symp 1987 (Neoplasms, Experimental) : Apart from their direct cytotoxic/cytostatic activities against tumours in vitro and in vivo, the in vivo antitumour activities of TNF-alpha or TNF-beta may involve the following biological activities : the induction of interleukin 1 production ; activation of polymorphonuclear neutrophil functions ; modulation of endothelial cell functions ; and augmentation of specific immune functions
Heaton et al., Cancer Res 1993 : These data suggest the interaction of IL-2 and the high-affinity IL-2 receptor on human PBMC or peripheral blood lymphocyte is required for maximal secretion of IL-1 beta, TNF-alpha, TNF-beta , and IFN-gamma
Sugiyama et al., Infect Immun 1996 : In contrast, LPS induced interleukin 1 activity in human gingival epithelial cells in culture, while LTA had little effect
Poulsen et al., Cytokine 1996 (Dermatitis, Atopic...) : The combination ION + PMA induced the highest levels of IL-2 , IL-4, IL-5, IFN-gamma and TNF-alpha, whereas maximal production of IL-6 and TNF-beta were induced by PHA and PHA + PMA, respectively
Lu et al., Eur J Immunol 1998 : Furthermore, in BA/F3 cells co-transfected with the STAT5A gene and IL-2R beta gene, the activation of the TNF-beta gene promoter by IL-2 was greatly promoted, whereas the TNF-beta gene promoter became IL-2-non-inducible if the STAT5A gene was substituted with a dominant negative STAT5A, i.e. a C-terminally truncated mutant
Worm et al., Immunology 1998 (Hypersensitivity) : Stimulation of human B cells with anti-CD40 + interleukin-4 ( IL-4 ) results not only in proliferation and immunoglobulin E ( IgE ) -production, but also increased production of the cytokine lymphotoxin-alpha (LT-alpha) ( formerly also known as tumour necrosis factor-beta (TNF-beta) )