◀ Back to ATF4
ATF4 — CREB1
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Schinelli et al., J Neurosci 2001
:
By using selective protein kinase inhibitors and expression of dominant negative Rap1 protein, we also found that the Rap1/PKC/ERK dependent pathway
induces the phosphorylation of
activating transcription factor-1 , CREB, and Elk-1, whereas the p38MAPK dependent pathway only causes
CREB phosphorylation
Kajimura et al., J Exp Med 2011
(Bone Resorption) :
We show that the sympathetic tone signals in the osteoblasts to inhibit
CREB ( cAMP-responsive element binding protein ) phosphorylation and thus decrease osteoblast proliferation and to
promote ATF4 phosphorylation and thus increase RANKL ( receptor activator of NF-?B ligand ) expression, which then stimulates osteoclast differentiation
Cho et al., BMC systems biology 2013
:
The three key things from the in silico simulation and experimental results are : 1 ) palmitate induces different signaling pathways ( PKR ( double stranded RNA activated protein kinase ), PERK ( PKR-like ER kinase ), PKA ( cyclic AMP ( cAMP ) -dependent protein kinase A ) in a time dependent-manner, 2 ) both
ATF4 and CREB1 ( cAMP-responsive element binding protein 1 ) interact with the Atf4 promoter to contribute to a prolonged accumulation of ATF4, and 3 )
CREB1 is
involved in ER-stress induced apoptosis upon palmitate treatment, by regulating ATF4 expression and possibly Ca2+ dependent-CaM ( calmodulin ) signaling pathway