Gene interactions and pathways from curated databases and text-mining

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Text-mined interactions from Literome

Eriksson et al., Clin Exp Allergy 2001 (Hypersensitivity, Immediate) : The atopic subjects produced significantly lower IFN-gamma in response to Lep d 2.01 as compared to the non-atopics
Raso et al., Br J Pharmacol 2002 : Here we have studied the effect of leptin on expression of IFN-gamma induced nitric oxide synthase (iNOS) and cyclo-oxygenase-2 (COX-2), both prominent markers of macrophage activation, using the murine macrophage J774A.1 cell line
Meier et al., Cytokine 2003 (Obesity) : Leptin strongly enhanced the expression and secretion of the interferon-gamma-inducible protein ( IP-10 ) in a human monocytic cell line, as well as in peripheral blood mononuclear cells
Fantuzzi et al., Clin Exp Immunol 2005 (Colitis...) : Spontaneous production of IL-6 from colon cultures obtained from recipients of ob/ob cells was reduced compared to recipients of WT cells, whereas stimulation of lamina propria lymphocytes with leptin resulted in a higher IFNgamma release in recipients of ob/ob cells compared to recipients of WT cells
Simons et al., Cytokine 2005 : IFN-gamma also strongly reduced leptin production ( > or =85 % )
Chen et al., Neuroscience bulletin 2006 : Results Our data showed that leptin induced IFN-gamma production by PBMCs of patients in an acute phase of disease but not in a stable phase or in healthy controls