Ohnishi et al., Cancer Res 1990
:
We reported previously using a murine model that the kidney is the organ involved in catabolism of exogenous human recombinant interleukin 2 (IL-2) and that cathepsin D , a major renal acid protease, is responsible for the degradation of IL-2 Ohnishi et al., Tumour Biol 1989
:
Overall, these results demonstrated that the kidney is the organ to metabolize IL-2 and that cathepsin D , a renal acid protease, is involved in the degradation of IL-2