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CEBPB — PTGS2

Text-mined interactions from Literome

Wadleigh et al., J Biol Chem 2000 : Overexpression of c-Jun, C/EBPbeta, and C/EBPdelta enhances induction of the COX-2 reporter, while overexpression of cyclic AMP-response element binding protein or `` dominant negative '' C/EBPbeta represses COX-2 induction
Harrison et al., J Bone Miner Res 2000 : Overexpression of p20C/EBPbeta , a dominant negative inhibitor of C/EBP function, blocked the stimulation of PGHS-2 promoter activity by IL-1 and blocked the ability of overexpressed C/EBPbeta and C/EBPdelta to increase basal and IL-1 stimulated promoter activity ... These results suggest an essential role for C/EBPbeta and C/EBPdelta in the induction of PGHS-2 gene expression by IL-1 in osteoblastic cells
Ogasawara et al., J Biol Chem 2001 : These data suggest that C/EBP beta , AP-1, and CREB play crucial roles in the shear stress induced cox-2 expression in osteoblasts
Wang et al., Mol Pharmacol 2001 (Inflammation) : Because C/EBP beta, a basic leucine zipper transcription factor, can be activated via a PKC alpha/mitogen activated protein kinase pathway and can influence COX-2 expression, we examined whether C/EBP beta is involved in TPA induced epidermal COX-2 expression
Gagliardi et al., Oncogene 2001 (Cell Transformation, Viral) : The induction of the Cox-2 gene ( CEF-147 ) was also reduced by Delta184-C/EBPbeta
Gorgoni et al., J Biol Chem 2001 : The transcription factor C/EBPbeta is essential for inducible expression of the cox-2 gene in macrophages but not in fibroblasts ... The obligatory role of C/EBPbeta in COX-2 expression appeared to be mediated exclusively by the C/EBP element located at positions -138/-130 of the murine cox-2 promoter, and did not involve altered activity at the level of the other promoter elements described previously ( the -402/-392 NF-kappaB site, the -59/-48 CRE/E box element, and a potential second C/EBP site located at positions -93/-85 )
Cho et al., Mol Pharmacol 2003 : These results demonstrate that C2 increases C/EBP beta mediated COX-2 induction by LPS and that the pathway of JNK1 but not ERK1/2 is responsible for C/EBP beta activation involving activator protein-1 mediated enhanced C/EBP beta expression
Tamura et al., J Mol Endocrinol 2003 (Endometrial Neoplasms) : Employing electrophoretic mobility shift assays, we demonstrated that increased functional binding of CCAAT/enhancer binding protein ( C/EBP)alpha, C/EBPbeta and upstream stimulatory factor-2 to the CRE and C/EBPalpha and C/EBPbeta to the NF-IL6 site were, at least in part, responsible for MECM induced COX-2 expression in ESC ... Moreover, overexpression of C/EBPalpha and C/EBPbeta significantly induced COX-2 promoter activity in ESC ... Collectively, these results suggest that the basal and MECM induced transcription of the COX-2 gene in ESC is regulated through a combination of the CRE and the NF-IL6 site by functional interactions of C/EBPalpha and C/EBPbeta
Joo et al., J Biol Chem 2004 : Concomitantly, C/EBP-beta becomes acetylated, and expression of the COX-2 gene increases
Chen et al., Mol Biol Cell 2005 : MG132 induced DNA binding activity of C/EBPdelta, but not C/EBPbeta was regulated by p38, PI3K, Src, and protein kinase C. Small interfering RNA of C/EBPdelta suppressed COX-2 expression, further strengthening the role of C/EBPdelta in COX-2 gene transcription
Lee et al., Mol Hum Reprod 2005 : The role of CCAAT/enhancer binding protein beta in the transcriptional regulation of COX-2 in human amnion ... This suggests that although C/EBPbeta plays an essential constitutive role in the expression of COX-2 , C/EBPbeta may not be directly involved in its regulation in association with human labour
Regalo et al., J Pathol 2006 (Cell Transformation, Neoplastic...) : We also assessed the effect of C/EBPbeta on COX-2 expression ... Using GC cell lines we show that C/EBPbeta can regulate the expression of endogenous COX-2 and transactivate the promoter of the COX-2 gene, depending on its methylation status
Wu et al., Prostaglandins Other Lipid Mediat 2007 : Salicylate inhibits COX-2 transcriptional activation in quiescent cells but not in serum-driven proliferating cells by blocking C/EBPbeta DNA binding
He et al., Biochem J 2008 : These results demonstrate that LPA induces COX-2 expression and PGE ( 2 ) production through EGFR transactivation independent activation of transcriptional factors NF-kappaB and c-Jun, and EGFR transactivation dependent activation of C/EBPbeta in HBEpCs
Healy et al., Am J Physiol Cell Physiol 2008 : Individual gene knockdown experiments demonstrate the direct regulation of C/EBPbeta expression by c-Jun, and the critical roles of both c-Jun and C/EBPbeta in shear induced COX-2 synthesis
Dougherty et al., Clin Cancer Res 2008 (Colonic Neoplasms...) : Furthermore, in flat ACF, EGFR blockade decreased the up-regulation of c-Jun, FosB, phosphorylated active signal transducers and activators of transcription 3, and CCAAT/enhancer binding protein-beta , potential regulators of cyclin D1 and Cox-2
Sun et al., Am J Physiol Cell Physiol 2008 : COX-2 gene promoter deletion and mutation studies indicate a role of CCAAT/enhancer binding protein-beta ( C/EBP-beta ) in CT-induced COX-2 gene expression ... Our data suggest that the interaction between GR and C/EBP-beta contributes to elevated COX-2 gene transcription by CT in cardiomyocytes
Choi et al., Exp Brain Res 2009 (Brain Ischemia) : These results suggest that RA can reduce ischemia induced cerebral injury by an anti-inflammatory action, which may be effected via inhibition of C/EBPbeta mediated COX-2 induction
Pall et al., EMBO J 1997 : Since a reduction in C/EBP-beta expression does not affect the level of the ovulatory mediator prostaglandin endoperoxide synthase-2 ( PGS-2 ), these findings support the view of C/EBP-beta as an important factor in the ovulatory process and highlight a C/EBP-beta dependent and PGS-2 independent pathway that takes part in regulation of ovulation