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BDNF — MECP2
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Johnston et al., J Child Neurol 2005
(Rett Syndrome) :
Recent reports indicate that
MeCP2 controls the expression of
brain derived neurotrophic factor and the DNA binding homeobox protein Dlx5
Zhou et al., Neuron 2006
(Calcium Signaling...) :
Brain-specific phosphorylation of
MeCP2 regulates activity dependent
Bdnf transcription, dendritic growth, and spine maturation
Wang et al., J Neurosci 2006
:
Thus, the net
effect of
MeCP2 loss on absolute
BDNF secretion changes with age and is determined by both the amount of BDNF available for release and progressive declines in total cellular BDNF
Ogier et al., J Neurosci 2007
(Disease Models, Animal...) :
Therefore, the present study used Mecp2 null mice to further define the
role of
MeCP2 in regulation of
BDNF expression and neural function, focusing on NG neurons and respiratory control
Klein et al., Nat Neurosci 2007
:
Block of miR132 mediated repression increased MeCP2 and
brain derived neurotrophic factor (BDNF) levels in cultured rat neurons and the loss of
MeCP2 reduced BDNF and miR132 levels in vivo
Abuhatzira et al., Epigenetics 2007
:
Therefore, how
MeCP2 deficiency
causes an overall downregulation of
BDNF expression was an enigma
Larimore et al., Neurobiol Dis 2009
(Atrophy...) :
Indeed, endogenous Mecp2 knockdown increased the intracellular levels of BDNF protein compared to untransfected neurons, suggesting that
MeCP2 represses
Bdnf transcription ... Surprisingly, overexpression of wt
MECP2 also
increased BDNF levels, while overexpression of RTT associated MECP2 mutants failed to affect BDNF levels
Zeev et al., Neurology 2009
(Rett Syndrome) :
Brain derived neurotrophic factor (BDNF) is a neurotrophic factor playing a major role in neuronal survival, neurogenesis, and plasticity, and it has been shown that
BDNF expression is
regulated by
MeCP2 through a complex interaction
Im et al., Nat Neurosci 2010
(Cocaine-Related Disorders) :
MeCP2 controls
BDNF expression and cocaine intake through homeostatic interactions with microRNA-212
Vermehren-Schmaedick et al., Neuroscience 2012
(Anoxia...) :
In vitro studies using cultured neurons have produced conflicting results with respect to the
role of
MeCP2 in
BDNF expression ... The results indicate that
MeCP2 is
required for regulation of
BDNF expression by acute intermittent hypoxia in vivo