Pathways - manually collected, often from reviews:
OpenBEL Selventa BEL large corpus:
Complex of GRB2-IRS2
→
IL4
(increases)
Zamorano et al., Cell Res 2001* Evidence: association of phosphorylated IRS2 with GRB2 was not detected in resting B cells after IL4 treatment although both proteins were expressed IL4 induced association of IRS2 with GRB2 in B cell blasts
Kim et al., Endocrinology 1998
(Neuroblastoma) :
Treatment with PI 3-K inhibitors induced an increased association of IRS-2 with Grb2 , probably as a result of the increased IRS-2 tyrosine phosphorylation
Kim et al., J Biol Chem 1998
(Neuroblastoma) :
In contrast, IGF-I induces a transient tyrosine phosphorylation of IRS-2 and an association of IRS-2 with Grb2