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IGF1 — PDK1

Text-mined interactions from Literome

Collins et al., EMBO J 2003 : The knock-in ES cells were viable, mutant PDK1 was expressed at normal levels and insulin-like growth factor 1 induced normal activation of PKB and phosphorylation of the PKB substrates GSK3 and FKHR
Collins et al., J Cell Sci 2005 : The knockin ES cells were viable, mutant PDK1 was expressed at normal levels and IGF1 induced activation of protein kinase B ( PKB/Akt ), which is a PDK1 substrate that does not require hydrophobic motif phosphorylation to be activated
Alajajian et al., Neuroreport 2009 : IGF-I regulated phosphorylation and translocation of PDK-1 in neurons ... Furthermore, we found that IGF-I transiently increased phosphorylation of neuronal PDK-1 , resulting in its translocation to other cellular compartments ... Our findings suggest that IGF-I may regulate neuronal PDK-1 differently than in non-neuronal cells, which may indicate a novel role for PDK-1 in IGF-I mediated neuroprotective signaling
Shen et al., J Biol Chem 2010 : PDK1 recruitment was also required for IGF-I to prevent apoptosis that occurred in response to hyperglycemia
Wang et al., Biochim Biophys Acta 2012 (Ion Channel Gating) : Western blot analysis demonstrated that IGF-1 significantly increased the phosphorylation of phospholipid dependent kinase ( PDK ) at serine residue 241 ( Ser ( 241 ) ) and AKT at Ser ( 473 ) in the isolated medullary TAL ... Moreover, inhibition of PI3K with LY294002 abolished the effect of IGF-1 on the phosphorylation of PDK and AKT