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BCL2 — INS
Text-mined interactions from Literome
Ueno et al., Mol Biol Cell 2000
:
Overexpression of IRS-1 suppresses phosphorylation of
Bcl-2 induced by stimulation with
insulin , and the hypophosphorylation may lead to its enhanced antiapoptotic activity
Iida et al., Arterioscler Thromb Vasc Biol 2002
:
In the exploration of the signaling pathway involved in these antiapoptotic effects of insulin, pretreatment of cells with a specific inhibitor of phosphatidylinositol-3-kinase significantly suppressed insulin mediated cell survival and
insulin induced
Bcl-XL expression in macrophages
Augustin et al., Reproduction 2003
:
No
effects of
insulin on the mRNA expression of Glut isoforms and Bax and
Bcl-XL were found
Hui et al., Brain Res 2005
(Brain Ischemia) :
In contrast,
insulin , a PI3K agonist, not only obviously activated Akt1 during early and later reperfusion, but also
inhibited phosphorylation of JNK1/2, c-Jun, and
Bcl-2 and attenuated the activation of caspase-3
Jafari Anarkooli et al., Cell Mol Neurobiol 2009
(Body Weight...) :
Effects of
insulin and ascorbic acid on expression of
Bcl-2 family proteins and caspase-3 activity in hippocampus of diabetic rats were evaluated in this study
Navarro et al., Exp Cell Res 1998
:
Moreover,
insulin down-regulated
Bcl-xS expression without inducing the expression of Bcl-xL