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MBP — TNF

Text-mined interactions from Literome

Fujimoto et al., J Neuroimmunol 1999 (Disease Models, Animal...) : Ibudilast mildly suppressed MBP induced proliferation of T cells in regional lymph nodes, the secretion of interferon-gamma from T cells activated by MBP in CFA, and the secretion of tumor necrosis factor-alpha from macrophages
Huang et al., Int J Dev Neurosci 2002 (Multiple Sclerosis...) : Elucidating the molecular mechanisms underlying TNF-alpha regulation of MBP gene expression provides new scientific bases for the development of therapy against oligodendrocyte-specific and myelin related disorders such as multiple sclerosis
Hollifield et al., Autoimmunity 2003 (Multiple Sclerosis) : In contrast, MS patients in remission produced significantly less spontaneous and MBP induced TNF-alpha , spontaneous, PHA- and MBP induced IL-1beta and PHA induced IFN-gamma together with increased production of biologically active TGF-beta1
Lopez et al., J Interferon Cytokine Res 2003 : IFN-gamma ( 100 U/ml ) and TNF-alpha ( 1000 U/ml ) or IL-5 ( 200 pM ) caused a significant increase in the expression of the eosinophil peroxidase (EPO) and the major basic protein (MBP) genes
Jana et al., Free Radic Biol Med 2005 (Encephalomyelitis, Autoimmune, Experimental...) : Interestingly, both IL-1beta and TNF-alpha markedly inhibited the expression of MOG, CNPase, and PLP but not MBP , the effect that was blocked by antioxidants such as N-acetylcysteine (NAC) and pyrrolidine dithiocarbamate ( PDTC )
Hedegaard et al., Immunology 2008 (Multiple Sclerosis, Relapsing-Remitting) : The MBP induced a dose dependent release of interferon-gamma (IFN-gamma), tumour necrosis factor-alpha (TNF-alpha) and interleukin-10 (IL-10) by patient derived MNCs
Mann et al., Journal of neuroinflammation 2008 : Corticosterone, dihydrocorticosterone and, most prominently dexamethasone, counteracted the deleterious effects of IFN-gamma and TNF-alpha on cell survival, A2B5 immunostaining and expression of myelin basic protein
Navikas et al., Brain 1996 (Multiple Sclerosis...) : The MBP induced upregulation of TNF-alpha and LT was major histocompatibility complex ( MHC) class II molecule dependent
Stepaniak et al., J Neurosci Res 1996 (Encephalomyelitis, Autoimmune, Experimental) : Stimulation of cells from MBP73-84 : 1028 coimmunized protected rats proliferate and secrete interferon-gamma (IFN-gamma) and tumor necrosis factor-alpha (TNF-alpha) in vitro in response to MBP73-84