◀ Back to STAT3
MAP2K1 — STAT3
Pathways - manually collected, often from reviews:
-
NCI Pathway Database IL2-mediated signaling events:
STAT3 (STAT3)
→
MEK1-2 (MAP2K1/MAP2K2)
(modification, collaborate)
Delespine-Carmagnat et al., Eur J Immunol 2000, Fung et al., Cell Signal 2003, Nielsen et al., Eur J Immunol 1994, Frank et al., Proc Natl Acad Sci U S A 1995, Johnston et al., Proc Natl Acad Sci U S A 1995, Hou et al., Immunity 1995, Lin et al., Immunity 1995, Ng et al., J Biol Chem 1997
Evidence: mutant phenotype, assay, physical interaction
Text-mined interactions from Literome
Song et al., Oncogene 2004
(Cell Transformation, Neoplastic) :
Our results showed that
mitogen activated protein kinase kinase 5 ( MEK5 ) was markedly
induced ( more than 22-fold increase, P < 0.001 ) by
Stat3-C expression
Venkatasubbarao et al., Cancer Res 2005
(Adenocarcinoma...) :
Expression of constitutively active
MEK-1 caused an increase of ERK activity and
inhibited STAT3 ( ( Tyr705 ) ) phosphorylation
Sengupta et al., Proc Natl Acad Sci U S A 1998
:
Expression of constitutively active
MEK1 , the kinase that activates ERKs, or overexpression of ERK2, but not JNK1,
inhibited Stat3 activation