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Sun et al., Proc Natl Acad Sci U S A 2008
:
Although beta-arrestin 2 deficiency did not affect LPA induced IKKalpha/beta phosphorylation, it impaired LPA induced IKK kinase activity, which is consistent with our previous findings that CARMA3 is required for IKKalpha/beta activation but not for the inducible phosphorylation of IKKalpha/beta
Sun et al., J Biol Chem 2010
:
Furthermore, knockdown of PP2Ac expression enhances LPA induced MEKK3 mediated IkappaB kinase beta (IKKbeta) phosphorylation and NF-kappaB activation