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ATR — PRKDC

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Intact Interaction: Complex of 11 proteins (association, pull down) Izumi et al., Science signaling 2010
• IRef Intact Interaction: Complex of ATR-RUVBL2-TTI2-MTOR-ATM-TELO2-PRKDC-TTI1 (association, tandem affinity purification) Takai et al., Genes Dev 2010
• IRef Intact Interaction: Complex of 11 proteins (association, tandem affinity purification) Takai et al., Genes Dev 2010
• IRef Intact Interaction: Complex of ATM-TTI1-MTOR-ATR-PRKDC-SMG1 (association, anti tag coimmunoprecipitation) Hurov et al., Genes Dev 2010
• IRef Intact Interaction: Complex of PRKDC-TELO2-ATR (association, affinity chromatography technology) Takai et al., Cell 2007
• IRef Intact Interaction: Complex of MTOR-ATM-TELO2-ATR-PRKDC-TRRAP (association, anti bait coimmunoprecipitation) Takai et al., Cell 2007

Text-mined interactions from Literome

Müller et al., J Cell Biol 2007 : DNA-PK is activated during replication stress and DNA-PK signaling is enhanced when ATR/ATM signaling is abrogated
Gong et al., Mol Cell 2010 : ATR signaling was abrogated by shRNAs to ATR and TopBP1, but shRNAs to the ATM kinase or DNA-PKcs did not affect the telomere damage response