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Hu et al., Lung 2006 : AP-1 inhibitor curcumin also inhibited TGF-beta1 induced alpha-SMA expression ... Based on these findings, we conclude that p38 kinase, Erk, and AP-1 are responsible for the alpha-SMA expression induced by TGF-beta1 in human fetal lung fibroblasts
Hu et al., Arch Dermatol Res 2013 (Cicatrix, Hypertrophic...) : Then, we established HTSs in a rabbit ear model and determined the effect of MAPKs on the pathogenesis of HTSs. MAPK pathways were activated by CCN2 in HTSFs. Extracellular signal regulated kinase ( ERK ) and c-Jun N-terminal kinase (JNK) inhibitors significantly inhibited CCN2 induced expression of a-SMA and collagen I in HTSFs