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MYLIP — TNFSF10

Text-mined interactions from Literome

Acunzo et al., Oncogene 2012 (Carcinoma, Non-Small-Cell Lung...) : miR-130a targets MET and induces TRAIL-sensitivity in NSCLC by downregulating miR-221 and 222
Noguchi et al., Cell death & disease 2013 (Urinary Bladder Neoplasms) : Exogenous miR-145 in T24 and NKB1 cells markedly increased the expression levels of interferon ( IFN ) -ß, 2'-5'-oligoadenylate synthetase 1, which lies upstream of 2'-5 ' oligoadenylates/RNase L system, and TRAIL , and induced apparent caspase dependent apoptosis that was suppressed by cotreatment with a pan-caspase inhibitor ; moreover, these expression levels were reduced by cotreatment with an miR-145 inhibitor
Wang et al., FEBS J 2013 (Breast Neoplasms) : TRAIL induced miR-146a expression suppresses CXCR4 mediated human breast cancer migration ... A neutralization antibody against DR4 specifically blocked TRAIL induced NF-?B activation and miR-146a expression ... These results were confirmed in a human breast cancer xenograft mouse model, suggesting that TRAIL significantly enhanced miR-146a expression and suppressed CXCR4 expression, indicating that TRAIL induced miR-146a up-regulation is negatively associated with CXCR4 expression ... These findings suggest that TRAIL induced miR-146a expression suppresses CXCR4 mediated human breast cancer migration, and provide further insight into the non-apoptotic function of TRAIL in the prevention of metastasis as a therapy for breast cancer