Gene interactions and pathways from curated databases and text-mining

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IRF6 — ISG20

Text-mined interactions from Literome

Lin et al., Oncogene 2001 : vIRF-1 has been shown to downregulate the interferon- and IRF mediated transcriptional activation of ISG and murine IFNA4 gene promoters
Chiang et al., J Immunol 2006 : In this study we show that IRF3 mediated ISG induction by LPS requires the production of reactive oxygen species ( ROS ) by the NADPH dependent oxidase NOX4 ... ASK1 kinase activity proved essential for IRF3 mediated ISG induction by LPS