UCSC Genome Browser Gene Interaction Graph

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Gene interactions and pathways from curated databases and text-mining

NCI Pathway Database Hedgehog signaling events mediated by Gli proteins: Su(fu) (SUFU) → Su(fu)/SIN3/HDAC complex complex (SUFU-SIN3A-SAP30-SAP18-SIN3B-RBBP7-HDAC1-RBBP4-HDAC2) (modification, collaborate)
Cheng et al., Proc Natl Acad Sci U S A 2002, Paces-Fessy et al., Biochem J 2004
Evidence: assay, physical interaction, other species
NCI Pathway Database Hedgehog signaling events mediated by Gli proteins: SIN3/HDAC complex complex (SIN3A-SAP18-SAP30-SIN3B) → Su(fu)/SIN3/HDAC complex complex (SUFU-SIN3A-SAP30-SAP18-SIN3B-RBBP7-HDAC1-RBBP4-HDAC2) (modification, collaborate)
Cheng et al., Proc Natl Acad Sci U S A 2002, Paces-Fessy et al., Biochem J 2004
Evidence: assay, physical interaction, other species
NCI Pathway Database Hedgehog signaling events mediated by Gli proteins: SMO/beta Arrestin2 complex (SMO-ARRB2) → Su(fu)/SIN3/HDAC complex complex (SUFU-SIN3A-SAP30-SAP18-SIN3B-RBBP7-HDAC1-RBBP4-HDAC2) (modification, activates)
Cheng et al., Proc Natl Acad Sci U S A 2002, Paces-Fessy et al., Biochem J 2004, Haycraft et al., PLoS Genet 2005
Evidence: mutant phenotype, reporter gene, other species