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IRF6 — NEDD9

Text-mined interactions from Literome

Heissmeyer et al., Mol Cell Biol 2001 : In line with this and as a physiologically relevant model, lipopolysaccharide (LPS) induced degradation of endogenous p105 and p50 homodimer formation, but not processing in pre-B cells ... In mutant pre-B cells lacking IKKgamma, processing was unaffected, but LPS induced p105 degradation was abolished
Beinke et al., Mol Cell Biol 2004 (MAP Kinase Signaling System) : These data show that IKK induced p105 proteolysis is essential for LPS activation of TPL-2, thus revealing a novel function of IKK in the regulation of the ERK MAP kinase cascade
Ko et al., Planta Med 2005 : Our results also showed that LPS/IFN-gamma-stimulation resulted in the degradation of NF-kappaB p105 , the NF-kappaB precursor, and laxifolone A treatment significantly counteracted this effect
Babu et al., Biochim Biophys Acta 2006 : Recent studies demonstrate that the NF-kappaB1 precursor protein p105 functions as an inhibitor of Tpl2 and that the LPS stimulated Tpl2 activation requires p105 degradation
Minami et al., J Biol Chem 2008 (Atherosclerosis) : Similarly, directed EPRAP expression in RAW264.7 cells suppresses LPS induced p105 phosphorylation and degradation, and subsequent activation of mitogen activated protein kinase kinase 1/2 ... In EP4 overexpressing cells, PGE ( 2 ) enhances the protective action of EPRAP against stimulus induced p105 phosphorylation, whereas EPRAP silencing in RAW264.7 cells impairs the inhibitory effect of PGE ( 2 ) -EP4 signaling on LPS induced p105 phosphorylation