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IRF6 — MAP3K14
Text-mined interactions from Literome
Huang et al., J Biomed Sci 2003
:
We found that
LPS induced
I kappa B kinase and nuclear factor-kappa B (NF-kappa B) activation, as well as IFN-gamma induced signal transducer and activator of transcription 1 ( STAT1 ) phosphorylation, were reduced by lovastatin
Ma et al., Mol Pharmacol 2003
:
Analyses of the NF-kappaB activation pathway revealed that the antioxidants do not inhibit
LPS induced activation of the
IkappaB kinase activity, degradation of IkappaBalpha, or translocation of activated NF-kappaB into the nucleus, but they do block the formation of NF-kappaB/DNA binding complexes
Kim et al., Immunology 2005
:
Moreover, in vitro kinase assays show that luteolin directly inhibits
LPS induced
IkappaB kinase (IKK) activity in IEC-18 cells
Yanaka et al., Int J Mol Med 2005
:
Although vitamin B6 did not affect cellular proteasome activity, in vitro phosphorylation analysis with glutathione S-transferase fused IkappaBalpha has shown that vitamin B6 suppressed
LPS induced
IkappaB kinase activation
von Bülow et al., J Immunol 2007
(MAP Kinase Signaling System) :
By this mechanism, zinc suppressed
LPS induced
activation of
IkappaB kinase beta (IKKbeta) and NF-kappaB, and subsequent TNF-alpha production