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ADCY9 — IGF1
Text-mined interactions from Literome
Sadler et al., J Biol Chem 1987
:
In contrast,
insulin-like growth factor 1 stimulated in vivo phosphodiesterase, inhibited in vitro
adenylate cyclase , and induced oocyte maturation at concentrations of 0.3-1.0 nM ... These results demonstrate a dual
regulation of oocyte phosphodiesterase and
adenylate cyclase by insulin and
insulin-like growth factor 1
Hakeda et al., J Cell Physiol 1994
:
These results indicate that the production of
IGF-I and the expression of IGF-I receptors and IGFBP-2 are
up-regulated by the activation of
adenylate cyclase and protein kinase C, respectively, in osteoblastic MC3T3-E1 cells
Goad et al., Endocrinology 1993
:
Taken together, these findings indicated that
IGF-I did not
affect Gs alpha, coupling of Gs alpha to adenylate cyclase, or
adenylate cyclase itself
Fournier et al., J Endocrinol 1993
(Osteosarcoma) :
Neither
IGF-I nor IGF-II
had an effect on either the basal or the parathyroid hormone stimulated level of
adenylate cyclase activity, and likewise they had no effect on phosphodiesterase activity
Li et al., Exp Eye Res 1999
(Second Messenger Systems) :
SQ22536 ( 100 microM ), an
adenylate cyclase inhibitor, and H-89, a PKA inhibitor,
had no inhibitory effect on bFGF induced down-regulation of
IGF-I expression