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EPHB2 — STAR

Text-mined interactions from Literome

Gyles et al., J Biol Chem 2001 : We demonstrate that cyclic AMP induced steroid synthesis is dependent upon the phosphorylation and activation of ERKs and that ERK activation results in enhanced phosphorylation of SF-1 and increased steroid production through increased transcription of the StAR gene ... Similarly, ERK inhibition led to a reduction in the levels of FSK stimulated StAR mRNA, StAR protein, and steroid secretion
Yu et al., Frontiers in bioscience : a journal and virtual library 2005 : Immunocytochemical studies further revealed that ERK1/2 inhibition led to a reduction of mitochondrial StAR in the GCs by FSH
Manna et al., Mol Endocrinol 2006 : Interestingly, inhibition of ERK activity enhanced IGF-I mediated StAR protein expression, but phosphorylation of StAR was undetectable, an observation in contrast to that seen with N, O'-dibutyrl-cAMP signaling
Manna et al., J Mol Endocrinol 2006 : Inhibition of ERK activity enhanced TGFalpha mediated StAR protein expression ( but not its phosphorylation ) and decreased progesterone synthesis, events correlated with the expression of dosage-sensitive sex reversal, adrenal hypoplasia congenita, critical region on the X chromosome, gene 1 ( DAX-1 ) and scavenger receptor class B type 1 ( SR-B1 )
Krug et al., Int J Obes Relat Metab Disord 2007 : Adipokines induce aldosterone secretion from human adrenocortical cells and sensitization of the cells to stimulation by AngII, possibly mediated via ERK1/2 dependent upregulation of StAR activity
Johnston et al., Reproduction 2007 : Data indicate that both LH and ACTH, acting through their respective receptors, stimulate steroidogenesis by fetal-type Leydig cells via arachidonic acid, protein kinase A, and ERK1/2 activation of StAR
Poderoso et al., Mol Cell Endocrinol 2009 (MAP Kinase Signaling System) : We have demonstrated that ( a ) steroidogenesis in MA-10 Leydig cells depends on the specific of ERK1/2 activation at the mitochondria ; ( b ) ERK1/2 phosphorylation is driven by mitochondrial PKA and constitutive MEK1/2 in this organelle ; ( c ) active ERK1/2 interacts with StAR protein, leads to StAR protein phosphorylation at Ser ( 232 ) only in the presence of cholesterol ; ( d ) directed mutagenesis of Ser ( 232 ) ( S232A ) inhibited in vitro StAR protein phosphorylation by ERK1; (e) transient transfection of MA-10 cells with StAR S232A cDNA markedly reduced the yield of progesterone production
Lucki et al., Mol Cell Endocrinol 2012 (Calcium Signaling...) : S1P induced StAR mRNA expression requires Ga ( i ) signaling, phospholipase C (PLC), Ca ( 2+ ) /calmodulin dependent kinase II ( CamKII ), and ERK1/2 activation
Vleugels et al., Exp Clin Endocrinol Diabetes 2011 (MAP Kinase Signaling System...) : Our previous work shows a direct stimulatory effect of adipokines on aldosterone secretion from human adrenocortical cells, mediated via ERK1/2 dependent upregulation of steroid acute regulatory protein (StAR) activity