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ATF2 — MAPK6

Text-mined interactions from Literome

Brinkman et al., J Biol Chem 1999 : Engagement of tumor necrosis factor (TNF) receptor 1 leads to ATF-2- and p38 mitogen activated protein kinase dependent TNF-alpha gene expression
Crowe et al., Anticancer Res 2000 (Carcinoma, Squamous Cell...) : Of these, little is known about the role of ATF-2 in regulation of MAPK signaling and cellular proliferation
Yosimichi et al., Eur J Biochem 2001 : These inhibitors of MAPKK and MAPK suppressed phosphorylation of ets-like gene-1 (Elk-1) and nuclear activating transcription factor-2 ( Atf-2 ) induced by CTGF/Hcs24 in a dose dependent manner, respectively
Matsuoka et al., Am J Physiol Lung Cell Mol Physiol 2002 (Disease Models, Animal...) : p38 MAPK and its substrate, activating transcription factor (ATF)-2, in bronchoalveolar lavage fluid cells were phosphorylated by intratracheal exposure of bleomycin, and the phosphorylation of ATF-2 was inhibited by subcutaneous administration of a specific inhibitor of p38 MAPK, FR-167653
Cao et al., Mol Cell Biol 2004 : Activation of ATF-2 by p38 MAPK additionally serves as the cAMP sensor that increases expression of the PGC-1alpha gene itself in brown adipose tissue
Ha et al., Proc Natl Acad Sci U S A 2004 : Here, we demonstrate an additional mechanism whereby a significant reduction of proinflammatory gene expression such as IL-1beta, tumor necrosis factor alpha, and inducible nitricoxide synthase in PARP-1 ( -/- ) glial cells is linked to defective inflammatory stimuli induced p38MAPK mediated phosphorylation of ATF-2 and cAMP-response element binding protein and phosphorylation of NF-kappaB p65
Faour et al., J Biol Chem 2005 (Arthritis, Rheumatoid) : Initial studies confirmed that PGE2 induces egr-1 mRNA expression and protein synthesis by restricted SAPK2/p38 MAPK dependent activating transcription factor-2 ( ATF-2) dimer transactivation of the egr-1 promoter as judged by studies using wild-type ( WT ) and deletion mutant egr-1 promoter constructs, Northern and Western blotting, and standard and supershift electrophoretic mobility shift analyses
Si et al., J Virol 2005 : JNK1/2 inhibitors reduced CVB3 induced phosphorylation of activating transcription factor 2 , and the p38 MAPK inhibitor reduced CVB3 induced phosphorylation of heat shock protein 27
Sooranna et al., J Cell Physiol 2007 (MAP Kinase Signaling System) : All three stimuli increased PGHS-2 and IL-8 mRNA expression in a MAPK dependent manner, but while the MAPK inhibitors reduced the IL-1beta induced activation of activating transcription factor (ATF)-2 , liver activating protein (LAP) and c-jun, the stretch induced increase in LAP was unaffected by MAPK-inhibition and only JNK inhibition appeared to reduce c-jun activation
Huang et al., Journal of molecular signaling 2008 : It appears that this effect is mediated through p38 MAPK, because RA decreased p38 phosphorylation, and a selective inhibitor of p38 MAPK ( SB203580 ) also inhibited the phosphorylation of ATF-2
Hisatsune et al., J Immunol 2008 : Molecular characterization of Helicobacter pylori VacA induction of IL-8 in U937 cells reveals a prominent role for p38MAPK in activating transcription factor-2 , cAMP response element binding protein, and NF-kappaB activation
Cho et al., Mol Endocrinol 2009 : The inhibition of MAPK dependent activating transcription factor 2/c-Jun phosphorylation by GR in COX-2 repression was a result of MAPK phosphatase-1 (MKP-1) induction
Zdanov et al., Biogerontology 2009 : In this work, p38 ( MAPK ) activation and increased DNA binding activities of ATF-2 and p53 are shown to mediate cyclooxygenase-2 overexpression in premature senescence
Truter et al., Cardiology 2009 (Aortic Valve Insufficiency...) : JNK and p38MAPK inhibition reduced c-Jun and ATF2 phosphorylation to NL ; ERK inhibition had no effect
Liss et al., Oncogene 2010 (Cell Transformation, Neoplastic...) : Investigating the mode of ATF2 regulation revealed a positive feedback mechanism whereby ATF2 induces p38 MAPK phosphorylation to further induce its own activity
Liu et al., Int J Biochem Cell Biol 2010 : Taken together, our data indicate that Fas/FasL up-regulation in piceatannol treated U937 cells is elicited by Ca ( 2+ ) /p38alpha MAPK mediated activation of c-Jun and ATF-2 , and suggest that autocrine Fas mediated apoptotic mechanism is involved in piceatannol induced cell death
Wilkinson et al., Genes Dev 1996 : ATF-2 is regulated through phosphorylation in mammalian cells by the stress activated mitogen activated protein ( MAP ) kinases SAPK/JNK and p38
Chen et al., J Biol Chem 1998 (Brain Neoplasms) : The involvement of p38 ( MAPK ) in the activation of ATF-2 , which leads to the transactivation of rat grp78, is confirmed by electrophoretic mobility shift assay using a probe containing the CRE-like sequence as well as by transient transfection assays with a plasmid containing a 710-base pair stretch of the grp78 promoter
Cheong et al., J Biol Chem 1998 : We demonstrate that p38beta mitogen activated protein ( MAP ) kinase augments ATF-2 transactivation activity on the PEPCK-C promoter, which is consistent with the interpretation that PEPCK-C promoter activity is maintained under stress through a p38 MAP kinase dependent pathway