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CCNE1 — CDKN1A

Pathways - manually collected, often from reviews:

• BioCarta p53 signaling pathway: CDK2/CYCLIN E/PCNA complex (CDK2-CCNE1-PCNA) → p21 (CDKN1A) (modification, activates)
• BioCarta cell cycle: g1/s check point: Cyclin E/CDK2 complex (CCNE1-CDK2) → p21 (CDKN1A) (modification, activates)
• KEGG Cell cycle: CDKN1A → Complex of CCNE1-CCNE2-CDK2 (protein-protein, inhibition)
  
• KEGG p53 signaling pathway: CDKN1A → Complex of CCNE1-CCNE2-CDK2 (protein-protein, inhibition)
  
• NCI Pathway Database Regulation of retinoblastoma protein: CDK2/Cyclin E1 complex (CDK2-CCNE1) → p21CIP1/CDK2 complex (CDKN1A-CDK2) (modification, activates)
  Harbour et al., Cell 1999, Chan et al., Nat Cell Biol 2001, Rubin et al., Cell 2005
  Evidence: mutant phenotype, assay, reporter gene, physical interaction
• NCI Pathway Database Signaling events mediated by PRL: p21CIP1 (CDKN1A) → CDK2/Cyclin E1 complex (CDK2-CCNE1) (modification, activates)
  
• WikiPathways Retinoblastoma (RB) in Cancer: CDKN1A → Complex of CDK2-CCNE1 (mim-inhibition)
• WikiPathways miRNA Regulation of DNA Damage Response: CDKN1A → Complex of CDK2-CCNE2-CCNE1 (inhibition)
  
• WikiPathways Cell Cycle: CDKN1A → CCNE1/CCNE2 (inhibition)
• WikiPathways ATM Signaling Pathway: CDKN1A → CCNE1 (mim-inhibition)
• WikiPathways DNA Damage Response: CDKN1A → Complex of CDK2-CCNE2-CCNE1 (inhibition)
  

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind_translation Interaction: CDKN1A — CCNE1 (coimmunoprecipitation) Poon et al., J Biol Chem 1996
• IRef Bind_translation Interaction: CDKN1A — CCNE1 (coimmunoprecipitation) Orend et al., Oncogene 1998
• IRef Biogrid Interaction: CDKN1A — CCNE1 (physical association, affinity chromatography technology) Derjuga et al., J Biol Chem 2001*
• IRef Biogrid Interaction: CDKN1A — CCNE1 (direct interaction, pull down) Chen et al., Mol Cell Biol 1996
• IRef Biogrid Interaction: CDKN1A — CCNE1 (physical association, affinity chromatography technology) Levkau et al., Mol Cell 1998*
• IRef Biogrid Interaction: CDKN1A — CCNE1 (physical association, affinity chromatography technology) Poon et al., J Biol Chem 1996
• IRef Biogrid Interaction: CDKN1A — CCNE1 (physical association, affinity chromatography technology) Zhao et al., Genes Dev 1998*
• IRef Biogrid Interaction: CDKN1A — CCNE1 (direct interaction, two hybrid) Wang et al., Molecular systems biology 2011
• IRef Biogrid Interaction: CDKN1A — CCNE1 (physical association, affinity chromatography technology) McKenzie et al., Cancer Res 2003*
• IRef Biogrid Interaction: CDKN1A — CCNE1 (physical association, affinity chromatography technology) Jeon et al., J Biol Chem 2007*
• IRef Biogrid Interaction: CDKN1A — CCNE1 (physical association, affinity chromatography technology) Datta et al., Cell Growth Differ 1998
• IRef Biogrid Interaction: CDKN1A — CCNE1 (physical association, affinity chromatography technology) Orend et al., Oncogene 1998
• IRef Biogrid Interaction: CDKN1A — CCNE1 (physical association, affinity chromatography technology) Wu et al., Oncogene 1997*
• IRef Biogrid Interaction: CDKN1A — CCNE1 (physical association, affinity chromatography technology) Liu et al., J Immunol 1997*
• IRef Biogrid Interaction: CDKN1A — CCNE1 (physical association, affinity chromatography technology) Bresnahan et al., Cell Growth Differ 1996*
• IRef Biogrid Interaction: CDKN1A — CCNE1 (physical association, affinity chromatography technology) Bendjennat et al., Cell 2003*
• IRef Biogrid Interaction: CDKN1A — CCNE1 (physical association, affinity chromatography technology) Bao et al., FEBS Lett 2006*
• IRef Biogrid Interaction: CDKN1A — CCNE1 (physical association, affinity chromatography technology) Chen et al., Mol Cell Biol 1996
• IRef Dip Interaction: CDKN1A — CCNE1 (physical association, coimmunoprecipitation) Harper et al., Cell 1993*
• IRef Hprd Interaction: CDKN1A — CCNE1 (in vitro) Chen et al., Mol Cell Biol 1996
• IRef Hprd Interaction: Complex of CDKN1A-CCNE1-CDK2-CDK2-CCNE1-CDKN1A-CCNE1-CDK2-CDKN1A (in vivo) Bao et al., FEBS Lett 2006*
• IRef Hprd Interaction: Complex of CDK2-CCNE1-ESR1-CDKN1A (in vivo) Maynadier et al., FASEB J 2008*
• IRef Hprd Interaction: Complex of 16 proteins (in vivo) Maynadier et al., FASEB J 2008*
• IRef Hprd Interaction: Complex of 17 proteins (in vivo) Kashiwagi et al., Oncogene 2000*
• IRef Intact Interaction: CDKN1A — CCNE1 (physical association, anti bait coimmunoprecipitation) Bao et al., FEBS Lett 2006*
• IRef Intact Interaction: CDKN1A — CCNE1 (physical association, two hybrid) Wang et al., Molecular systems biology 2011
• IRef Intact Interaction: CDKN1A — CCNE1 (physical association, pull down) Chen et al., Mol Cell Biol 1996
• IRef Intact Interaction: CDKN1A — CCNE1 (physical association, anti bait coimmunoprecipitation) Chen et al., Mol Cell Biol 1996
• IRef Intact Interaction: Complex of CCNE1-CDKN1A-CDK2 (association, pull down) Chen et al., Mol Cell Biol 1996
• IRef Intact Interaction: Complex of 18 proteins (association, tandem affinity purification) Varjosalo et al., Cell reports 2013
• IRef Intact Interaction: Complex of 30 proteins (association, tandem affinity purification) Varjosalo et al., Nat Methods 2013
• IRef Intact Interaction: Complex of 11 proteins (association, tandem affinity purification) Varjosalo et al., Cell reports 2013
• IRef Ophid Interaction: CDKN1A — CCNE1 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Ariazi et al., Cancer Res 1999 (Mammary Neoplasms, Animal) : RNA expression studies, based on a multiplexed-nuclease protection assay, demonstrated that cell cycle- and apoptosis related genes were differentially expressed within 48 h of POH treatment ; p21 ( Cip1/WAF1 ), bax, bad, and annexin I were induced ; cyclin E and cyclin dependent kinase 2 were repressed ; and bcl-2 and p53 were unchanged
Li et al., J Biol Chem 2002 : p21 binds to and inhibits both the DNA synthesis regulator proliferating cell nuclear antigen and cyclin A/E-CDK2 complexes