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CXCL12 — RHOA

Text-mined interactions from Literome

Soede et al., J Immunol 2001 : Stromal cell derived factor-1 induced LFA-1 activation during in vivo migration of T cell hybridoma cells requires Gq/11, RhoA , and myosin, as well as Gi and Cdc42
Vicente-Manzanares et al., J Immunol 2002 : SDF-1alpha induced activation of RhoA , but not that of Rac
Parmo-Cabañas et al., Exp Cell Res 2004 (Multiple Myeloma) : Furthermore, a functional link between cAMP actions on the dynamics of actin cytoskeleton, RhoA activation, and alpha4beta1 dependent cell adhesion in response to SDF-1alpha has been found
Bartolomé et al., Cancer Res 2004 (Lymphatic Metastasis...) : Moreover, SDF-1alpha triggered the activation of the GTPases RhoA, Rac1, and Cdc42 on BLM cells, and expression of dominant negative forms of RhoA and Rac1, but not Cdc42, substantially impaired the invasion of transfectants in response to SDF-1alpha, as well as the increase in MT1-MMP expression
Matsusaka et al., Biochem Biophys Res Commun 2005 : CXCL12 stimulation led to prompt activation of RhoA, but expression of DN-Syk suppressed RhoA activation
Petreaca et al., Mol Biol Cell 2007 : Furthermore, inhibition of the VEGFR abolishes RhoA activation by IL-8/CXCL8 , and gap formation, suggesting a mechanism whereby VEGFR2 transactivation mediates IL-8/CXCL8 induced permeability
Badr et al., PloS one 2011 (Multiple Myeloma) : Activation of CXCR4 by CXCL12 resulted in the association of CXCR4 with CD45 and activation of PLCß3, AKT, RhoA , I?Ba and ERK1/2
Badr et al., PloS one 2012 (Multiple Myeloma) : We found that WEV and WEV+NP clearly decreased the CXCL12/CXCR4 mediated activation of AKT, ERK, NF?B and Rho-A using western blot analysis ; abrogated the CXCL12 mediated proliferation of MM cells using the CFSE assay ; and induced apoptosis in MM cell as determined by PI/annexin V double staining followed by flow cytometry analysis