Gene interactions and pathways from curated databases and text-mining

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E2F5 — MYC

Pathways - manually collected, often from reviews:

  • FastForward regulation: E2F5 → MYC (transcriptional regulation, increase) Chen et al., Cell 2002
    Evidence: REG, PROMACTIVITY, DNABINDING
  • KEGG Cell cycle: Complex of E2F4-E2F5-RBL1-RBL2-TFDP1-TFDP2 → MYC (gene expression, repression)
  • KEGG TGF-beta signaling pathway: Complex of E2F4-E2F5-RBL1-RBL2-TFDP1 → MYC (gene expression, repression)

Text-mined interactions from Literome

Beier et al., EMBO J 2000 : In these cells, activation of Myc stimulates transcription of E2F target genes, S-phase entry and cell growth without affecting cyclin E-cdk2 kinase activity
Lang et al., J Biol Chem 2001 (Osteosarcoma) : TRRAP and GCN5 co-expression stimulated E2F mediated transactivation, and c-Myc repressed E2F transactivation dependent on an intact TRRAP/GCN5 binding motif
Leone et al., Mol Cell 2001 : Myc requires distinct E2F activities to induce S phase and apoptosis
Chen et al., Hypertension 2006 (MAP Kinase Signaling System) : Both ET and c-Myc increased expression and promoter activity of E2F , a transcription factor that has been linked to enhanced cell cycle activity
Hiebert et al., Proc Natl Acad Sci U S A 1989 : We conclude that the activation of the E2F factor, which is likely responsible for the activation of viral E2 transcription, is also responsible for the E1A dependent induction of MYC transcription
Oswald et al., Oncogene 1994 : E2F dependent regulation of human MYC : trans-activation by cyclins D1 and A overrides tumour suppressor protein functions