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MYC — PLAU

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: MYC → Complex of PLAU-PLAUR (increases, PLAU/PLAUR Activity)
  Evidence: In addition to the influence on the protein kinase system, uPA can regulate gene expression. The binding of uPA to uPAR has been shown to stimulate downstream up-regulation of various transcription factors: AP1 in the HT-1080 cell line [54] and c-Jun, c-Myc, and c-fos factors in SaOS2 cells [55]. Recently, the possibility of signal transduction into the cell by the receptor systems associated with urokinase endocytosis was shown [56].
• WikiPathways Wnt Signaling Pathway and Pluripotency: EP300 → Complex of 11 proteins (activation)
• WikiPathways Wnt Signaling Pathway and Pluripotency: ZBTB33 → Complex of 11 proteins (mim-inhibition)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: PLAU — MYC (direct interaction, two hybrid) Wang et al., Molecular systems biology 2011
• IRef Intact Interaction: MYC — PLAU (physical association, two hybrid array) Wang et al., Molecular systems biology 2011

Text-mined interactions from Literome

Hou et al., Cardiovasc Res 2007 (Anoxia) : c-Myc is essential for urokinase plasminogen activator expression on hypoxia induced vascular smooth muscle cells ... The purpose of this study was to investigate whether c-Myc regulates expression of urokinase plasminogen activator (uPA) on hypoxia induced vascular smooth muscle cells ( VSMCs ) ... The results show that c-Myc was essential for hypoxia induced uPA expression and activity, resulting in VSMC migration and invasion
Alfano et al., Mol Cell Biol 2010 : Thus, the differential regulation of uPA and uPAR by c-Myc and Ras correlates with the effects of these two oncoproteins on cell motility, invasiveness, and survival