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JAK2 — MAPK3

Text-mined interactions from Literome

Takaoka et al., EMBO J 1999 : Protein tyrosine kinase Pyk2 mediates the Jak dependent activation of MAPK and Stat1 in IFN-gamma, but not IFN-alpha, signaling
Wang et al., Oncogene 2000 : PD180970 did not affect MAPK activation by PDGF or the JAK dependent activation of Stat3 by interleukin-6
Krasilnikov et al., Oncogene 2003 (Melanoma) : Tyrosine phosphorylation of STAT3/5 and of JAK2 also increased upon treatment of LU1205 cells with either PD or LY, suggesting that constitutive active MAPK and PI3K signals inhibit tyrosine phosphorylation of JAK/STATs
Shi et al., J Biol Chem 2004 : Although Pyk2 has been implicated in Janus kinase dependent activation of MAPK and Stat1, no role for Pyk2 in the activation of other STAT proteins has been ascribed
Banes-Berceli et al., Vascul Pharmacol 2005 (Diabetes Mellitus, Experimental) : Allopurinol ( xanthine oxidase inhibitor, 1 microM ) and l-NAME ( nitric oxide synthase inhibitor, 1 mM ) had no effect on ET-1 induced JAK2 activation, while apocynin ( NAD ( P ) H oxidase inhibitor 100 microM ) resulted in a significant inhibition of ET-1 induced JAK2 and MAPK activation
Ogunwobi et al., Endocrinology 2006 (Adenocarcinoma...) : The activation of ERK and Akt but not p38 MAPK was JAK2 dependent
Kanda et al., Endocrinology 2007 (MAP Kinase Signaling System...) : Prolactin induced phosphorylation of JAK2 and ERK, whereas IFN-gamma induced phosphorylation of JAK1, JAK2, and p38 MAPK
Kang et al., Cell Prolif 2008 (MAP Kinase Signaling System) : These results indicate that IL-6 is directly involved in Erk1/2 activation via JAK2 and that Erk1/2 provides a signal bridge between the IL-6 induced JAK2/STAT3 pathway and EGF induced MAPK pathway
Yung et al., Cell Signal 2008 (MAP Kinase Signaling System) : In contrast, inhibitors of JAK2 , phospholipase C, protein kinase C and Ca ( 2+ ) /calmodulin dependent kinase II did not affect the ability of NGF to activate p38 MAPK
Chen et al., Int J Biochem Cell Biol 2008 (MAP Kinase Signaling System) : Inhibition of Janus kinase 2 prevented the adenosine induced steroidogenesis and phosphorylation of mitogen activated protein kinase kinase 1/2 and extracellular signal regulated kinase 1/2 , demonstrating that Janus kinase 2 was the upstream effector of the mitogen activated protein kinase kinase pathway
Rychli et al., Journal of thrombosis and haemostasis : JTH 2010 : Oncostatin M (OSM) increased Ang2 expression in human umbilical vein endothelial cells via Janus kinase/signal transducer and activator of transcription ( JAK/STAT ) and mitogen activated protein ( MAP ) kinase activation
Liontos et al., J Immunol 2011 : In bone marrow derived DC ( BM-DC ) lacking SLAP and the closely related SLAP2, downregulation of GM-CSFRß is impaired, leading to enhanced phosphorylation of Jak2 and prolonged activation of Akt and Erk1/2 in response to GM-CSF stimulation
Winston et al., J Biol Chem 1995 : JAK2 , Ras, and Raf are required for activation of extracellular signal regulated kinase/mitogen activated protein kinase by growth hormone ... We have used a transient transfection system in 293 cells to evaluate the requirement for JAK2 in the activation of ERK2/MAPK by GH ... We found that JAK2 is required for GH-simulated activation of ERK2/MAPK ... Employing the transient expression of dominant negative forms of H-Ras and Raf-1, we determined that the GHR/JAK2 mediated activation of ERK2/MAPK is dependent on both Ras and Raf
Pratt et al., J Biol Chem 1996 : Several downstream signaling events induced by GM-CSF stimulation have been described, including activation of tyrosine kinases and tyrosine phosphorylation of cellular proteins ( including beta c ) and activation of the Ras/mitogen activated protein kinase and the JAK/STAT pathways
Schiemann et al., J Biol Chem 1997 : Coexpression of dominant negative Jak2 inhibited chimeric receptor stimulated MAPK activity by approximately 70 %, while expression of dominant negative Ras completely blocked MAPK activation by either receptor polypeptide