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MAPK14 — PTX3
Text-mined interactions from Literome
Liu et al., Brain Res Mol Brain Res 1999
:
Interestingly, a wortmannin-sensitive phosphatidylinositol 3-kinase and a
pertussis toxin ( PTX ) -sensitive G protein form part of the molecular pathways
mediating MAPK activation by AMPA receptor
Sodhi et al., Int Immunopharmacol 2002
:
The expression of phospho-p42/44
MAPK was
inhibited by the MAPK inhibitor, PD98059,
pertussis toxin ( PTX ) , tyrosine kinase inhibitor-genistein and P13K inhibitor-wortmannin
Hashimoto et al., Mol Cell Biochem 2001
(Bone Neoplasms...) :
Both CTX and
PTX completely blocked the stimulatory action of AlF3 on MAPK tyrosine phosphorylation, but neither toxin
had an effect on the action of NaF on
MAPK tyrosine phosphorylation
Nishioka et al., Eur J Immunol 2003
(MAP Kinase Signaling System) :
Pertussis toxin ( PTX ) inhibits all these neutrophil functions and the
MAPK activation caused by HP-NAP
Chiou et al., Int Immunopharmacol 2004
:
We found that C5a induced, time dependent ( 1 ) ERK1/2 phosphorylation was markedly diminished by PTX, U73122, P13K inhibitors wortmannin and LY294002 and ERK1/2 inhibitor PD98059 ; ( 2 ) Akt phosphorylation was also attenuated by the above inhibitors except PD98059 ; ( 3 ) p38
MAPK phosphorylation was only
affected by
PTX
Coimbra et al., J Trauma 2004
(Sepsis) :
These results suggest that
PTX-inhibition of oxidative burst occurs distal to PKC and may be either
due to direct inhibition of NADPH oxidase or inhibition of
MAPK phosphorylation, leading to decreased adhesion molecule expression and TNF-alpha synthesis
Deree et al., Surgery 2007
(MAP Kinase Signaling System) :
We investigated the
effects of
HS/PTX on human neutrophil
mitogen activated protein kinase ( MAPK ) signaling and the role of Protein kinase A (PKA) in this process ... Both
PTX and HS
reduced p38MAPK phosphorylation
Tsai et al., Neuroscience 2009
(Hyperalgesia...) :
Ultra-low dose naloxone plus morphine significantly inhibited the
effect of
PTX on P-p38
MAPK expression in the spinal cord, while the p38 MAPK inhibitor SB203580 attenuated the PTX induced mechanical allodynia, thermal hyperalgesia, increase in spinal cerebrospinal fluid excitatory amino acids, and downregulation of GTs
Zhou et al., International journal of molecular sciences 2009
:
In addition,
pertussis toxin ( PTX ) , a Gi protein inhibitor,
induced an inhibitory effect on p38
MAPK , ERK phosphorylation and RASMCs migration
Satomura et al., Mod Rheumatol 2013
(Arthritis, Rheumatoid...) :
Furthermore, SAA induced
PTX3 expression was
inhibited by NF-?B or
mitogen activated protein kinase-specific inhibitors
Kirsz et al., Postepy Hig Med Dosw 2012
(Obesity...) :
Activation of the G protein Gq/11 subunit causes a
pertussis toxin ( PTX ) -insensitive
activation of both phospholipase C and
mitogen activated protein kinase ( MAP ) , and activation of the Go subunit causes a PTX-sensitive inhibition of adenyl cyclase
Conway et al., Biochem J 1999
:
Furthermore, the
PTX dependent decrease in c-Src and p42/p44
MAPK activation appeared correlated