Smiley et al., J Immunol 2001
:
Nevertheless, fibrinogen- and LPS induced chemokine secretion both apparently required expression of functional Toll-like receptor 4 , as each was diminished in macrophages derived from C3H/HeJ mice
Andonegui et al., Blood 2005
(Inflammation...) :
Here we demonstrate that although platelets do not increase P-selectin expression in response to LPS, platelets bind more avidly to fibrinogen under flow conditions in a Toll-like receptor-4 (TLR4) dependent manner
Hodgkinson et al., Thromb Haemost 2008
(Inflammation) :
The effect of fibrinogen on polymorphic variant TLR4s was markedly different ; enhancing activation of kinases, transcription factors, cytokine synthesis and promoter activity ... This study indicates that fibrinogen activates TLR4 , explaining how fibrinogen promotes inflammatory protein expression