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TCF25 — TLR4
Text-mined interactions from Literome
Wietek et al., J Biol Chem 2003
:
Interferon regulatory factor (IRF) 3 is a
transcription factor that binds the interferon-sensitive response element ( ISRE ) and is
activated by Toll-like receptor 3 (TLR3) and
TLR4
Youn et al., Int Immunopharmacol 2008
:
Selenium suppresses the activation of
transcription factor NF-kappa B and IRF3
induced by TLR3 or
TLR4 agonists
Scanzello et al., Curr Opin Rheumatol 2008
(Chronic Disease...) :
TLRs are expressed and functional in the joint, and many proteases and cytokines that promote cartilage catabolism are dependent on nuclear factor-kappaB, a
TLR activated
transcription factor
Sun et al., Circ Res 2009
:
TLR signaling via p38
led to phosphorylation and activation of the
transcription factor Microphthalmia transcription factor, acting at E-box elements in the Ctsk promoter
Marsh et al., J Neurosci 2009
(Infarction, Middle Cerebral Artery...) :
TLR4 can
induce both IFNbeta and interferon stimulated genes through its adapter molecule Toll/interleukin receptor domain containing adaptor inducing IFNbeta ( TRIF ) and the IRF3
transcription factor
Hankins et al., J Biol Chem 2011
:
TLR4 signaling ultimately
leads to activation of the
transcription factor , nuclear factor ?B ( NF-?B ), and the production of cytokines