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PTGS2 — PTH

Text-mined interactions from Literome

Huang et al., J Bone Miner Res 2010 : Parathyroid hormone induction of cyclooxygenase-2 in murine osteoblasts : role of the calcium-calcineurin-NFAT pathway ... Single mutation of CRE, AP-1, or NFAT sites decreased parathyroid hormone (PTH) stimulated COX-2 promoter activity 40 % to 60 %, whereas joint mutation of NFAT and AP-1 abrogated the induction ... These results indicate an important role for the calcium-calcineurin-NFAT signaling pathway in the PTH induction of COX-2 and suggest that cross-talk between the cAMP/PKA pathway and the calcium-calcineurin-NFAT pathway may play a role in other functions of PTH in osteoblasts
Xu et al., Bone 2010 (Body Weight...) : Because PTH is a potent inducer of COX-2 and prostaglandin ( PG ) production, we examined the effects of COX-2 KO on bone responses after 3 weeks of intermittent PTH
Choudhary et al., Bone 2013 : PTH also induces cyclooxygenase-2 (COX-2) , producing prostaglandin E2 ( PGE2 ) that can act on both OBs and osteoclasts ( OCs ) ... PTH increased OB differentiation in BMSCs only in the absence of COX-2 expression or activity
Kawaguchi et al., J Bone Miner Res 1996 (Bone Resorption) : IL-1 and tumor necrosis factor-alpha (TNF-alpha), both at 1-100 ng/ml, and PTH at 0.1-10 nM increased PGHS-2 and cPLA2 mRNA and medium PGE2 levels dose-dependently after 4 h of treatment ... We conclude that ( 1 ) IL-1, TNF-alpha, and PTH , but not IL-6 nor IL-11, can increase the expression of PGHS-2 , cPLA2, and PGE2 production in cultured mouse calvariae ; ( 2 ) IL-4 inhibits PGE2 production in both control and stimulated calvarial cultures by inhibiting PGHS-2 and cPLA2 ; and ( 3 ) IL-4 has an inhibitory effect on bone resorption which is independent of PG production
Tetradis et al., Endocrinology 1996 : Bovine PTH- ( 1-34 ) at 0.01-10 nM increased PGHS-2 , but not PGHS-1, messenger RNA ( mRNA ) levels ... However, treatment of cells with 30 microM H-89, a protein kinase A inhibitor, significantly reduced the ability of PTH and forskolin to induce PGHS-2 mRNA levels ... Moreover, PTH- ( 3-34 ) at 0.1-100 nM did not induce PGHS-2 mRNA levels ... Our results show that PTH can rapidly and transiently induce PGHS-2 mRNA levels in osteoblastic MC3T3-E1 cells, primarily via the cAMP-protein kinase A signal transduction pathway
Maciel et al., J Rheumatol 1997 : Induction of cyclooxygenase-2 by parathyroid hormone in human osteoblasts in culture ... PTH induced COX-2 mRNA expression and PGE2 production ... These results show that PTH induces COX-2 expression in human osteoblasts in culture and suggest that this isoenzyme is the main factor in the control of prostaglandin synthesis in these experimental conditions
Tokushima et al., Adv Exp Med Biol 1997 : These findings suggest that PGHS-2 induced by PTH may regulate osteoclast formation by different mechanism from that induced by IL-1 beta