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PRKCE — PTGS2
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Xuan et al., Circulation 2005
(MAP Kinase Signaling System) :
In mice preconditioned with six 4-minute coronary occlusion/4-minute reperfusion cycles, we found that ( 1 ) ischemic PC activates the Raf1-mitogen activated protein kinase ( MAPK ) /extracellular signal regulated kinase kinase ( MEK) 1/2-p44/42 MAPK signaling pathway, induces phosphorylation of STAT1 and STAT3 on the Ser-727 residue, and upregulates COX-2 expression ; ( 2 ) pSer-STAT1 and pSer-STAT3 form complexes with pTyr-p44/42 MAPKs in preconditioned myocardium, supporting the concept that Ser phosphorylation of these 2 factors is mediated by activated p44/42 MAPKs ; and ( 3 ) activation of the Raf-1-MEK-1/2-p44/42 MAPK-pSer-STAT1/3 pathway and induction of
COX-2 during ischemic PC are
dependent on
protein kinase C (PKC)-epsilon activity, as determined by both pharmacological and genetic inhibition of PKCepsilon
Wu et al., Life Sci 2006
:
Here, we first showed that in rat cortical neuronal cells, LTA might activate protein tyrosine kinase ( PTK ), phosphatidylcholine-specific phospholipase C ( PC-PLC ), and phosphatidylinositol-specific phospholipase C ( PI-PLC ) to induce
protein kinase Cepsilon activation, which in turn induces extracellular signal regulated kinase ( ERK ) activation, finally
inducing PGE ( 2 ) release and
COX-2 synthesis