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EGFR — PTGS2

Text-mined interactions from Literome

Niki et al., Am J Pathol 2002 (Adenocarcinoma...) : To see whether EGFR signaling is involved in cox-2 and laminin-5 expression, we further conducted in vitro analyses using six lung adenocarcinoma cell lines ( A549, HLC-1, ABC-1, LC-2/ad, VMRC-LCD, and L27 )
Tortora et al., Clin Cancer Res 2003 (Neovascularization, Pathologic) : COX-2 expression can be induced by EGFR activation and is regulated by cAMP and PKA
Ashida et al., Exp Dermatol 2003 (MAP Kinase Signaling System) : Inhibition of EGFR by a specific inhibitor and by a neutralizing antibody suppressed the induction of COX-2 expression by UV
Araki et al., Lung Cancer 2004 (Adenocarcinoma...) : Epidermal growth factor receptor (EGFR) signaling regulates Cox-2 expression, which has not been thoroughly examined in bronchial carcinomas
Moraitis et al., Cancer Res 2005 : Both an inhibitor of EGFR tyrosine kinase activity and a neutralizing anti-EGFR antibody blocked TS-mediated induction of COX-2 ... Taken together, these results suggest that activation of EGFR signaling contributes to the elevated levels of COX-2 found in the oral mucosa of smokers
Richardson et al., Lung Cancer 2005 (Carcinoma, Non-Small-Cell Lung...) : Cyclooxygenase-2 protein levels are independent of epidermal growth factor receptor expression or activation in operable non-small cell lung cancer
Johnson et al., J Exp Ther Oncol 2004 (Carcinoma, Squamous Cell...) : Cyclooxygenase-2 induction and prostaglandin E2 accumulation in squamous cell carcinoma as a consequence of epidermal growth factor receptor activation by imatinib mesylate
Han et al., J Biol Chem 2005 (Cholangiocarcinoma...) : On the other hand, activation of EGFR by its cognate ligand ( EGF ) increased COX-2 expression and PGE2 production, whereas blocking PGE2 synthesis or the EP1 receptor inhibited EGF induced EGFR phosphorylation
Zhang et al., Invest Ophthalmol Vis Sci 2005 (Optic Nerve Injuries) : Activation of the epidermal growth factor receptor in optic nerve astrocytes leads to early and transient induction of cyclooxygenase-2 ... In rat optic nerve transection and a rat optic nerve explant culture model, the relationship between the expression of COX-2 and activation of EGFR was examined ... Activation of EGFR caused the rapid and transient induction of COX-2 in optic nerve astrocytes ... When COX-2 was induced in response to activation of EGFR , the activated astrocytes produced and released the proinflammatory mediator, PGE ( 2 ), in a time dependent manner ... The data demonstrate that the activation of EGFR in optic nerve astrocytes leads to the induction of the immediate early gene COX-2 and subsequent signaling through the synthesis of PGE ( 2 )
Wu et al., Am J Physiol Lung Cell Mol Physiol 2005 : These data suggest that p38 and EGFR kinase mediated Akt activation is required for Zn2+ induced COX-2 expression and that the PI3K/Akt signaling pathway plays a central role in this event
Merchant et al., Surgery 2005 (Colonic Neoplasms) : We have shown that activation of the EGFR induces up-regulation of cyclooxygenase 2 , basolateral release of prostaglandins (PGs), and mitogenesis in a polarizing human colon cancer cell line, HCA-7
Shida et al., World J Gastroenterol 2005 (Colonic Neoplasms) : Lysophosphatidic acid transactivates both c-Met and epidermal growth factor receptor , and induces cyclooxygenase-2 expression in human colon cancer LoVo cells
Han et al., J Cell Physiol 2006 (Carcinoma, Hepatocellular...) : Overexpression of COX-2 in cultured HCC cells ( Hep3B ) or treatment with PGE ( 2 ) or the selective EP ( 1 ) receptor agonist, ONO-DI-004, increased EGFR phosphorylation and tumor cell invasion ... Moreover, activation of EGFR by EGF increased COX-2 promoter activity and protein expression in Hep3B and Huh-7 cells, whereas blocking PGE ( 2 ) synthesis or EP ( 1 ) attenuated EGFR phosphorylation induced by EGF, suggesting that the COX-2/PGE ( 2 ) /EP ( 1 ) pathway also modulate the activation of EGFR by its cognate ligand
Han et al., J Biol Chem 2006 : In parallel, activation of COX-2/PGE ( 2 ) signaling also enhances Stat3 phosphorylation and reporter activity through EP ( 1 ) receptor induced activation of c-Src and EGFR in these cells
Park et al., Clin Cancer Res 2006 (Lung Neoplasms) : To characterize the radiation enhancing effects and underlying mechanisms of combined treatment with celecoxib, a cyclooxygenase-2 selective inhibitor, and gefitinib, an epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor , in human lung cancer cells
Half et al., Cancer Lett 2007 (Colonic Neoplasms) : Anti-EGFR and ErbB-2 antibodies attenuate cyclooxygenase-2 expression and cooperatively inhibit survival of human colon cancer cells ... In conclusion, EGFR and ErbB-2 regulate ERK mediated COX-2 expression and their selective inhibition enhanced NS-398 induced cell death
Pham et al., J Cell Physiol 2008 : The p38 ( MAPK ) selective inhibitor, SB202190, but not the MEK selective inhibitor, PD98059, or the EGFR kinase inhibitor, AG1478, inhibited Ang II-dependent COX-2 expression and CREB phosphorylation
Wu et al., Mol Med 2007 (Neoplasm Recurrence, Local...) : We previously reported that the epidermal growth factor receptor (EGFR) is overexpressed in papilloma cells, that cyclooxygenase-2 (COX-2) is induced, and that COX-2 expression in primary papilloma cells requires activation of the EGFR but not Erk
Liu et al., Am J Respir Cell Mol Biol 2007 : EGFR signaling is required for TGF-beta 1 mediated COX-2 induction in human bronchial epithelial cells ... COX-2 induction by TGF-beta1 depended upon Smad3 signaling and required the activity of EGFR or its downstream mediators ... These findings emphasize the central role of EGFR signaling in COX-2 induction by TGF-beta1 and suggest that inhibition of EGFR signaling should be investigated further for lung cancer prevention
Xu et al., Cancer Res 2007 (Brain Neoplasms...) : EGFR activation results in enhanced cyclooxygenase-2 expression through p38 mitogen activated protein kinase dependent activation of the Sp1/Sp3 transcription factors in human gliomas ... The p38-MAPK pathway can activate the Sp1/Sp3 transcription factors and this seems necessary for EGFR dependent transactivation of the COX-2 promoter ... Analysis of COX-2 promoter/luciferase constructs revealed that transcriptional activation of the COX-2 promoter by EGFR requires the Sp1 binding site located at -245/-240 ... Thus, EGFR activation in malignant gliomas can transcriptionally activate COX-2 expression in a process that requires p38-MAPK and Sp1/Sp3
Banu et al., Cell Prolif 2007 (Colonic Neoplasms) : Furthermore, specific inhibition of COX-2 with NS-398 reduced EGFR phosphorylation in colorectal cancer cells
Papaetis et al., Curr Pharm Des 2007 (Carcinoma, Non-Small-Cell Lung...) : In the present paper we have thoroughly reviewed the existing evidence of novel agents currently studied in clinical trials, focusing on epidermal growth factor receptor family inhibitors, angiogenesis inhibitors, cyclooxygenase-2 inhibitors , Bcl-2 targeted agents, protein kinase C inhibitors, proteasome inhibitors, farnesyl transferase inhibitors and retinoids
Buchanan et al., Cancer Res 2007 (Colorectal Neoplasms...) : The inhibition of EGFR also induced the down-regulation of COX-2 and further inhibited prostaglandin E2 formation
Gadgeel et al., Cancer 2007 (Carcinoma, Non-Small-Cell Lung...) : Therefore, it was hypothesized that tumor EGFR mutation status may influence the effectiveness of simultaneous EGFR and COX-2 inhibition in patients with NSCLC
Fukata et al., Gastroenterology 2007 (Chronic Disease...) : Mechanistically, we show that TLR4 is responsible for induction of Cox-2 , increased prostaglandin E ( 2 ) production, and activation of EGFR signaling in chronic colitis
He et al., Biochem J 2008 : Downregulation of EGFR by siRNA or pretreatment with the EGFR tyrosine kinase inhibitor, AG1478, partly attenuated LPA induced COX-2 expression and phosphorylation of C/EBPbeta ; however, neither of these factors had an effect on the NF-kappaB and JNK pathways ... These results demonstrate that LPA induces COX-2 expression and PGE ( 2 ) production through EGFR transactivation independent activation of transcriptional factors NF-kappaB and c-Jun, and EGFR transactivation dependent activation of C/EBPbeta in HBEpCs
Hsieh et al., Biochim Biophys Acta 2008 : Moreover, thrombin stimulated activation of NF-kappaB, AP-1, and COX-2 promoter activity was blocked by the inhibitors of c-Src, PKC, EGFR , MEK1/2, AP-1 and NF-kappaB, suggesting that thrombin induces COX-2 promoter activity mediated through PKC ( delta ) /c-Src dependent EGFR transactivation, MEK-ERK1/2, AP-1, and NF-kappaB
Dillon et al., Endocr Relat Cancer 2008 (Breast Neoplasms...) : Clinical and molecular studies implicate human epidermal growth factor receptor 2 ( HER2 ) in the regulation of COX-2 expression
Herrera et al., Rev Recent Clin Trials 2008 (Uterine Cervical Neoplasms) : The evidence supporting the biological rational to combine novel non-cytotoxic agents with CRT is strong, and drugs targeting different molecular pathways are currently under clinical development ( EGFR inhibitors, COX-2 inhibitors , hypoxia targeted agents, etc )
Zhang et al., Mol Cancer Res 2008 (Carcinoma, Squamous Cell...) : These results suggest that EGFR and MAPK are required for COX-2 induction by bradykinin
Khafif et al., Laryngoscope 2009 (Carcinoma, Squamous Cell...) : Curcumin decreased COX-2 expression and inhibited phosphorylation of EGFR in SCC-1 cells
Kim et al., Mol Cancer Res 2009 : Cyclooxygenase-2 (COX-2) negatively regulates expression of epidermal growth factor receptor and causes resistance to gefitinib in COX-2 overexpressing cancer cells ... Overexpression of COX-2 specifically down-regulated EGFR expression at the level of transcription ... Overexpressed COX-2 negatively regulates EGFR expression via JNK activation, leading to gefitinib resistance ... The ability of COX-2 to inhibit EGFR expression and gefitinib effects may have significance in clinical cancer therapy
Lo et al., Mol Cancer Res 2010 (Brain Neoplasms...) : Increased expression of EGFR/EGFRvIII and activated STAT3 leads to the synergistic activation of the COX-2 promoter ... Promoter mutational analysis identified a proximal STAT3 binding site that is required for EGFR/EGFRvIII-STAT3 mediated COX-2 gene activation
Frey et al., Lab Invest 2010 (Colonic Neoplasms) : ErbB4 stimulated COX-2 induction was associated with an increase in mRNA half-life and was blocked by inhibition of Src, phosphatidylinositol (PI) 3-kinase, or epidermal growth factor receptor (EGFR)
Hernandez et al., BMC gastroenterology 2010 (Colitis...) : Lastly, PGE 2 treatment increased mucosal expression of AR and Cox-2 , thus inducing EGFR activation and forming a positive feedback mechanism to amplify mucosal Cox-2
Chang et al., Toxicology 2011 : Involvement of the epidermal growth factor receptor in Pb²+ induced activation of cPLA2/COX-2 genes and PGE2 production in vascular smooth muscle cells ... Furthermore, Pb²+ induced activation of the COX-2/cPLA2 genes was inhibited by both epidermal growth factor receptor (EGFR) inhibitors ( AG1478 and PD153035 ) and EGFR siRNA
Chou et al., Toxicol Lett 2011 : NF-?B inhibitor BAY 11-7082 suppressed Pb²+ induced COX-2 mRNA expression, and EGFR inhibitors AG1478 and PD153035 as well as EGFR small interfering RNA reduced the coincident nuclear translocation of NF-?B
Hobbs et al., Am J Physiol Gastrointest Liver Physiol 2011 : We hypothesized that COX-2 induction and cell survival signaling downstream of TNF are mediated by EGFR transactivation
Hirota et al., Am J Physiol Gastrointest Liver Physiol 2012 : Epidermal growth factor receptor transactivation is required for proteinase activated receptor-2 induced COX-2 expression in intestinal epithelial cells ... Trypsin increased COX-2 expression through PAR(2) in Caco-2 cells and in an EGFR dependent manner in the noncancerous intestinal epithelial cell-6 cell line
McElroy et al., PloS one 2012 : Epidermal growth factor receptor (EGFR) activation prevents experimental NEC and may play a critical role in LPS stimulated COX-2 production ... We hypothesized that EGFR is required for LPS induction of COX-2 expression ... EGFR tyrosine kinase inhibitors block LPS stimulation of mitogen activated protein kinase ERK, suggesting an important role of the MAPK/ERK pathway in EGFR mediated COX-2 expression
Mustafi et al., Carcinogenesis 2012 (Cell Transformation, Neoplastic...) : To dissect EGFR signals in vitro, we examined colon cancer cells in monoculture or in cocultures with fibroblasts for EGFR transactivation and prostaglandin synthase 2 (PTGS2) induction ... Coculture increased Caco-2 phospho-active ERBB ( pERBB2 ), whereas DN-EGFR in Caco-2 cells suppressed fibroblast PTGS2 and prostaglandin E2 ( PGE2 )
Lao et al., Carcinogenesis 2012 (Cell Transformation, Neoplastic...) : Transformed COX-2+/+ and COX-2-/- keratinocytes expressed similar levels of H-ras, epidermal growth factor receptor and phospho-extracellular signal regulated kinase1/2 in vitro ; and COX-2-deficiency did not reduce uninfected or v-H-ras infected keratinocyte replication
Hsia et al., Mol Pharmacol 2013 (Breast Neoplasms...) : Strikingly, independent of its kinase activity, the elevated EGFR at least partly stabilized COX-2 expression by enhancing the binding of HuR to COX-2 mRNA
Xu et al., Mol Cancer Res 2013 (Glioma) : EGFR signaling, through activation of the p38-MAPK/PKC-d/Sp1 cascade, plays an essential role in the regulation of COX-2 expression in glioma cells
Sierra et al., Am J Physiol Gastrointest Liver Physiol 2013 (Helicobacter Infections) : Induction of COX-2 expression by Helicobacter pylori is mediated by activation of epidermal growth factor receptor in gastric epithelial cells
Coffey et al., Proc Natl Acad Sci U S A 1997 : EGFR blockade reduces baseline COX-2 immunoreactivity, PG levels, and mitogenesis in a concentration dependent manner ... These findings show that activation of the EGFR stimulates COX-2 production and its translocation to the nucleus, vectorial release of PGs, and mitogenesis in polarized HCA-7 Colony 29 cells