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IGF1 — RBL2
Text-mined interactions from Literome
Ceacareanu et al., Am J Physiol Cell Physiol 2006
:
We report that
IGF-I induces phosphorylation of
p130 ( cas ) and activation of Rac1 and that NO attenuates these effects
Fagerström et al., J Biol Chem 1998
(Neuroblastoma) :
The TPA induced p130cas phosphorylation increased within 5 min of stimulation and persisted for at least 4 days, whereas
bFGF/IGF-I induced
p130cas phosphorylation was biphasic
Casamassima et al., J Biol Chem 1998
:
Insulin-like growth factor I stimulates tyrosine phosphorylation of
p130 ( Cas ), focal adhesion kinase, and paxillin ...
IGF-I induced
p130 ( Cas ), p125(Fak), and paxillin tyrosine phosphorylation could be dissociated from mitogen activated protein kinase kinase, p70 ( S6K ), and protein kinase C activation ... In contrast, the structurally unrelated phosphatidylinositol 3-kinase inhibitors wortmannin and LY294002 markedly attenuated the increase in tyrosine phosphorylation of
p130 ( Cas ), p125(Fak), and paxillin
induced by
IGF-I ... Thus, our results identified a phosphatidylinositol 3-kinase dependent pathway that requires the integrity of the actin cytoskeleton to induce tyrosine phosphorylation of
p130 ( Cas ), p125(Fak), and paxillin in
response to
IGF-I and suggest that tyrosine phosphorylation of these focal adhesion proteins, together with the recruitment of c-Crk into a complex with p130 ( Cas ), may play a novel role in IGF-I signal transduction