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NFKB1 — TANK
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Leo et al., J Biol Chem 1999
:
A carboxyl-truncation mutant of CD40 lacking the last 32 amino acids required for
TRAF2 and TRAF3 binding, CD40 ( Delta32 ), mediated
NF-kappaB induction through a mechanism that was suppressible by co-expression of TRAF6 ( DeltaN ), a dominant negative version of TRAF6, but not by TRAF2 ( DeltaN ), implying that while TRAF6 does not directly bind CD40, it can participate in CD40 signaling
Bertrand et al., J Biol Chem 1999
:
Along with its protective effect, overexpressed
TRAF2 increased basal and insulin stimulated
NF-kappaB activities ... All effects were inhibited by IkappaB-alpha ( A32/36 ), suggesting that an amplification loop involving
TRAF2 activation of
NF-kappaB is implicated in insulin antiapoptotic signaling
Pomerantz et al., EMBO J 1999
:
TANK is a TRAF binding protein that can inhibit the binding of TRAFs to receptor tails and can also
inhibit NF-kappaB activation by these receptors ... Kinase-inactive TBK1 inhibits
TANK mediated
NF-kappaB activation but does not block the activation mediated by TNF-alpha, IL-1 or CD40
Nomura et al., Genes Cells 2000
:
NF-kappaB activation through IKK-i dependent
I-TRAF/TANK phosphorylation ...
NF-kappaB activation by IKK-i is significantly
blocked by coexpression of the N-terminal domain of
I-TRAF , dominant negative TRAF2, and dominant negative NIK and IKK-beta
Zapata et al., J Biol Chem 2000
:
In contrast,
TRAF2 mediated
NFkappaB induction was partially inhibited by DTRAF1 ... Mutants of DTRAF1 lacking the N-terminal region inhibited
NFkappaB induction by either
TRAF2 or TRAF6
Takaori-Kondo et al., Biochem Biophys Res Commun 2000
:
TRAF3 blocked OX40-,
TRAF2 induced
NF-kappaB activation, but not NIK- and IKKalpha induced NF-kappaB activation, indicating that TRAF3 blocks the pathway between TRAF2 and NIK ... C-terminal deletion mutants as well as the N-terminal deletion mutant of TRAF3 inhibited
NF-kappaB activation
induced by OX40 or
TRAF2
Chung et al., Biochem Biophys Res Commun 2001
:
Expression of dominant negative form of
TRAF2 inhibits the synergistic effects of HCV core protein on
NF-kappaB activation, suggesting that HCV core protein potentiates NF-kappaB activation through TRAF2 ... Moreover, we demonstrate that HCV core protein potentiates
TRAF2 mediated
NF-kappaB activation via IKKbeta
Tada et al., J Biol Chem 2001
:
Critical
roles of
TRAF2 and TRAF5 in tumor necrosis factor induced
NF-kappa B activation and protection from cell death ... However, the exact
roles of
TRAF2 and TRAF5 in TNF induced
NF-kappaB activation still remain controversial ... Collectively, these results indicate that both
TRAF2 and TRAF5 are
involved in TNF induced
NF-kappaB activation and protection from cell death
Park et al., J Biol Chem 2002
:
NF-kappaB activation by TNF receptor associated death domain and
TRAF2 was inhibited by NS5A, whereas MEKK1 and IKKbeta dependent NF-kappaB activation was not affected, suggesting that NS5A may inhibit NF-kappaB activation signaled by TRAF2
Chang et al., Exp Cell Res 2002
:
Even though LTbetaR was shown to recruit TNF-receptor associated factor
(TRAF) 2 , 3, and 5, and to
induce cell apoptosis or
NF-kappaB activation, however, the downstream signaling leading to chemokine expression is not illustrated yet
Han et al., Biochem Biophys Res Commun 2003
:
Dominant negative forms of
TRAF2 and TRAF5 substantially
inhibited TweakR mediated
NF-kappa B activation, suggesting a role of TRAFs in regulating smooth muscle and endothelial cell function
Park et al., J Biol Chem 2003
(Hepatitis C) :
Because
TRAF2 is
required for the activation of both
NF-kappaB and c-Jun N-terminal kinase (JNK), we investigated HCV NS5A protein for its potential capacity to modulate TRAF2 mediated JNK activity
Kataoka et al., Mol Cell Biol 2004
:
FLIP ( p43 ) -induced
NF-kappaB activation was profoundly
blocked by the dominant negative
TRAF2
Hauer et al., Proc Natl Acad Sci U S A 2005
:
Paradoxically, suppression of
TRAF2/5 mediated NF-kappaB activation by TRAF3
resulted in enhanced transcriptional activity of TRAF6 mediated canonical
NF-kappaB emanating from CD40
Samuel et al., J Biol Chem 2006
:
Because
TRAF2 regulates
NF-kappaB activation, the effects of cIAP1 on TRAF2 mediated induction of NF-kappaB transcriptional activity were studied using reporter gene assays ... Expression of a fragment of cIAP1 encompassing the three BIR domains ( but not full-length cIAP1 ) greatly enhanced
TRAF2 induced increases in
NF-kappaB activity, providing a convenient assay for monitoring BIR dependent effects of cIAP1 on TRAF2 in cells
Ishizawa et al., Biol Cell 2006
:
xFADD and xRIP1 synergistically
induced the activation of AP-1 and
NF-kappaB , both of which were partially mediated by
TRAF2 ( tumour-necrosis-factor-receptor associated factor 2 ) and TAK1 ( transforming-growth-factor-beta activated kinase 1 )
Liuwantara et al., Diabetes 2006
:
Activation of
NF-kappaB by TNF receptor associated factor
(TRAF) 2 , TRAF6, NF-kappaB inducing kinase, or protein kinase D, which transduce signals downstream of Toll-like receptors, TNF receptors, and free radicals, respectively, were all potent activators of the A20 promoter
Garcia et al., J Virol 2007
:
The amino-terminal and central proline-rich motifs of STP-A were responsible for TRAF6 and TRAF2 interactions, respectively, and STP-A and TRAF6 interaction contributed to the majority of NF-kappaB activation, whereas STP-A and
TRAF2 interaction
played a minor role in
NF-kappaB activation
Yang et al., J Biol Chem 2008
:
Previous studies established that IFN activates NFkappaB through a classical NFkappaB pathway that results in IkappaBalpha degradation and formation of p50 containing NFkappaB complexes, as well as an alternative pathway that involves
NFkappaB inducing kinase and
TRAF2 , which results in the formation of p52 containing NFkappaB complexes
Royuela et al., Histol Histopathol 2008
(Prostatic Neoplasms) :
TNFalpha also exerts proliferation by p38 activation, or when
TRAF-2 simultaneously
induces the transcription factor
NF-kappaB by NIK
Blackwell et al., Mol Cell Biol 2009
(Lymphoma) :
Notably,
TRAF2 phosphorylation
increased both basal and inducible c-Jun and
NF-kappaB activities and rendered cells resistant to stress induced apoptosis
Garrison et al., Oncogene 2009
:
Here, we investigated the
role of
TRAF2 in c-IAP2/MALT1 induced
NF-kappaB activation
Thomas et al., Cancer Res 2009
:
Importantly, constitutive
TRAF2 phosphorylation
increased both basal and inducible
NF-kappaB activation and rendered Ha-Ras-V12 transformed cells resistant to stress induced apoptosis
Yamaguchi et al., Cell Biol Int 2009
(MAP Kinase Signaling System) :
We also found that JNKBP1 could enhance the
NF-kappaB activation
induced by TAK1 and
TRAF2 , and could promote TRAF2 polyubiquitination
Yuan et al., J Immunol 2009
:
Amphioxus TRAF1/2 and 3 molecules displayed various expression patterns in response to microbial infection, and some of them can attenuate the
NF-kappaB activation
mediated by human
TRAF2 and 6
Manna et al., J Biol Chem 2010
:
It
inhibits TRAF2 mediated
NF-kappaB activation but not TRAF6 mediated NF-kappaB DNA binding by preventing its association with
TANK ( TRAF for NF-kappaB )
Zhang et al., Mol Biol Cell 2010
:
The scaffold protein
TANK/I-TRAF inhibits
NF-kappaB activation by recruiting polo-like kinase 1
Alvarez et al., Nature 2010
:
Genetic evidence indicates that
TRAF2 is
necessary for the polyubiquitination of receptor interacting protein 1 (RIP1) that then serves as a platform for recruitment and stimulation of IkappaB kinase, leading to activation of the transcription factor
NF-kappaB
Rothe et al., Science 1995
:
TRAF2 mediated
activation of
NF-kappa B by TNF receptor 2 and CD40
Cheng et al., Genes Dev 1996
:
TANK , a co-inducer with TRAF2 of TNF- and CD 40L mediated
NF-kappaB activation ... In cotransfection experiments, TANK and
TRAF2 activate
NF-kappaB synergistically, requiring both the amino-terminal portion of TANK and the ring finger domain of TRAF2
Rothe et al., Proc Natl Acad Sci U S A 1996
:
TRAF2 is
required for CD40- and TNF mediated activation of the transcription factor
NF-kappa B ... Overexpression of
I-TRAF inhibits TRAF2 mediated
NF-kappa B activation signaled by CD40 and both TNF receptors
Lee et al., Proc Natl Acad Sci U S A 1996
:
We demonstrate here that
TRAF2 also
plays an important role in CD30 induced
NF-kappa B activation ... We also show that
TRAF2 mediated activation of
NF-kappa B plays a role in the activation of HIV transcription induced by CD30 cross linking
Tewari et al., Curr Opin Genet Dev 1996
:
Significantly,
TRAF2 mediates the activation of
NF-kappa B by both receptors
Devergne et al., Mol Cell Biol 1996
(Cell Transformation, Viral) :
NF-kappaB activation by LMP1 ( 1-231 ) is likely to be mediated by TRAF1/TRAF2 heteroaggregates since TRAF1 is unique among the TRAFs in coactivating NF-kappaB with LMP1 ( 1-231 ), a
TRAF2 dominant negative mutant can
block LMP1 ( 1-231 ) -mediated
NF-kappaB activation as well as TRAF1 coactivation, and 30 % of TRAF2 is associated with TRAF1 in EBV transformed B cells
Tsitsikov et al., Proc Natl Acad Sci U S A 1997
:
Transient overexpression of
TRAF2 , but not TRAF1,
induced NF-kappaB activation and HIV-1-long terminal repeat-driven transcription in the T cell line, KT3
Hsu et al., J Biol Chem 1997
:
Co-expression of ATAR with TRAF5, but not
TRAF2 ,
results in synergistic activation of
NF-kappaB , suggesting potentially different roles for TRAF2 and TRAF5 in post-receptor signaling
Brink et al., J Biol Chem 1998
:
TRAF2A thus represents a novel signal transduction protein, the expression of which can act to inhibit
TRAF2 dependent
NF-kappaB activation
Jang et al., Biochem Biophys Res Commun 1998
:
4-1BB mediated
NF-kappa B activation was
inhibited by a dominant
negative-TRAF2 or -NF-kappa B-inducing kinase (NIK)
Kawamata et al., J Biol Chem 1998
:
These results indicate that the
NF-kappaB activation resulting from OX40 stimulation is
mediated by both
TRAF2 and TRAF5, and is likely to be negatively modulated by TRAF3
Yamamoto et al., J Immunol 1998
:
This
NF-kappaB activation signal is
inhibited by dominant negative
TRAF2 or intact TRAF3, indicating that TRAF2 and TRAF3 works as a mediator and an inhibitor, respectively
Lee et al., Proc Natl Acad Sci U S A 1999
(Lymphoma, B-Cell) :
Specificities of CD40 signaling :
involvement of
TRAF2 in CD40 induced
NF-kappaB activation and intercellular adhesion molecule-1 up-regulation