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NA — NFKB1

Text-mined interactions from Literome

Shimada et al., Dig Dis Sci 1999 : TNF-alpha induced activation of NF-kappaB activity was suppressed by NAC , and H2O2 caused significant activation of NF-kappaB
Verhasselt et al., J Immunol 1999 : We first found that NAC inhibited the constitutive as well as the LPS induced activity of the transcription factor NF-kappaB
Mohan et al., Am J Physiol 1999 : However, cytokine induced NF-kappaB activation and VCAM-1 expression are blocked by both PDTC and NAC
Marumo et al., Diabetes 1999 : VEGF induced NF-kappaB activation was inhibited by TLCK and NAC , but not by PD 98059
Kim et al., J Korean Med Sci 2000 (Acute Disease...) : Present study aims to investigate whether neutrophils primed by 4beta-phorbol 12beta-myristate 13alpha-acetate ( PMA ) affect the productions of H2O2 and lipid peroxide (LPO), NF-kappaB activation and cytokine production in pancreatic acinar cells, and whether these alterations were inhibited by N-acetylcysteine (NAC) and superoxide dismutase ( SOD )
Origuchi et al., J Lab Clin Med 2000 : We also demonstrated immunohistochemically that NAC inhibited NFkappaB nuclear translocation ... These results suggested that NAC inhibited both COX-2 expression and NFkappaB nuclear translocation in MG63, which in turn indicated that NAC could inhibit the inflammatory process involved in bone resorption by regulating COX-2 expression at the level of transcription
Parmentier et al., Eur Respir J 2000 : Under the same conditions, NF-kappaB binding was activated by LPS and NAC increased this LPS mediated effect
Hayashi et al., Neurol Res 2001 (Carotid Artery Injuries...) : Immunohistochemical and Western blotting studies demonstrated that NAC suppressed the injury induced NF-kappaB activity in the medial SMC layer
Pajonk et al., Free Radic Biol Med 2002 : NAC blocked radiation induced NF-kappaB activity in ECV 304 cells and RAW 264.7 macrophages, as measured by a gel shift assay, at doses that inhibited proteasome activity ... This provides a possible mechanism whereby NAC could block NF-kappaB activation and affect the expression of other molecules that are dependent on the ubiquitin/proteasome system for their degradation, other than by scavenging free radicals
Day et al., Am J Physiol Lung Cell Mol Physiol 2002 : In contrast, NF-kappaB activation by bleomycin is inhibited by U-0126, but not by NAC
Mazzeo et al., Cytokine 2002 : NAC did not inhibit p40 or p35 mRNA expression in dendritic cells or THP-1 cells, or NF-kappa B activation in THP-1 cells
Hashizume et al., Leuk Res 2002 : Both NAC and PDTC suppressed NF-kappaB binding activity to consensus DNA probe, and this result was correlated with a suppressive effect to CD11a/LFA-1alpha expression
Fan et al., Arch Biochem Biophys 2003 : The MGO-BSA induced NFkappaB activation was prevented in the presence of PD98059, NAC , and parthenolide, a selective inhibitor of NFkappaB
Takada et al., J Biol Chem 2003 : Unexpectedly, however, like TNF induced activation, H2O2 induced NF-kappaB activation was blocked by the calpain inhibitor N-Ac-Leu-Leu-norleucinal , suggesting that a proteosomal pathway was involved
Hayakawa et al., EMBO J 2003 : This hypothesis is mainly based on the findings that N-acetyl-L-cysteine (NAC) and pyrrolidine dithiocarbamate ( PDTC ), compounds recognized as potential antioxidants, can inhibit NF-kappaB activation in a wide variety of cell types ... Here we reveal that both NAC and PDTC inhibit NF-kappaB activation independently of antioxidative function
Lean et al., J Clin Invest 2003 (Bone Resorption) : Furthermore, in vitro NAC prevented osteoclast formation and NF-kappaB activation
Min et al., Biochem Biophys Res Commun 2003 : Furthermore, plasminogen stimulated CREB and NF-kappaB DNA binding activity, and this activation was also reduced by trolox and NAC
Jafari et al., Respirology 2004 (Respiratory Distress Syndrome, Adult) : NAC blocked stretch induced NF-kappa B and AP-1 binding and inhibited IL-8 mRNA expression
Shi et al., J Cardiovasc Pharmacol 2004 : However, NAC only partially inhibited the TNFalpha induced activation of NF-kappaB , but abolished the activation of SP-1
Chae et al., Immunopharmacol Immunotoxicol 2004 : The addition of NAC ( N-acetyl cysteine ), free radical scavenger, completely prevented TNF-alpha induced activation of NF-kappaB
Onyango et al., Neurobiol Dis 2005 (Alzheimer Disease...) : NF-kappa B activation and cybrid viability are enhanced by NAC
Farid et al., Nutrition & metabolism 2005 : Both curcumin, a component of the spice turmeric, and N-acetylcysteine (NAC) , an antioxidant, inhibit activation of NF-kappaB by inflammatory stimuli, albeit by different mechanisms ... In contrast, NAC prevented the increase in NF-kappaB activity induced by unloading but did not prevent losses of muscle mass or function ... In conclusion, neither dietary curcumin nor dietary NAC prevents unloading induced skeletal muscle dysfunction and atrophy, although dietary NAC does prevent unloading induced NF-kappaB activation
Mackenzie et al., Free radical research 2006 (Neuroblastoma) : Consistent with this, LA and NAC prevented zinc deficiency induced activation of the early steps of NF- kappaB ( IkappaBalpha phosphorylation ) and AP-1 [ c-Jun-N-terminal kinase (JNK) and p38 phophorylation ] cascades, and the high NF-kappaB- and AP-1-DNA binding activities in total cell extracts
Li et al., Acta Pharmacol Sin 2006 (Pulmonary Disease, Chronic Obstructive) : Similarly, NAC inhibited the activation of NF-kB induced by TNF- alpha, but had no effect on the activation of NF-kappaB induced by IL-1 ... The electrophoretic mobility shift assay also showed that PDTC and NAC do not directly inhibit NF-kappa B DNA binding activity in vitro
Eisner et al., FEBS Lett 2006 : NFkappaB activation and procaspase-3 and -9 fragmentation were prevented by NAC and IGF-1
Sury et al., Free Radic Biol Med 2006 (MAP Kinase Signaling System) : Intriguingly, NAC had no effect on the initial activation ( i.e., IkappaB degradation, nuclear p65 translocation, and Ser536 phosphorylation ) of NF-kappaB by TNF-alpha
Chung et al., Toxicological sciences : an official journal of the Society of Toxicology 2007 : Upregulation of NF-kappaB and COX-2 expression by AcQ treatment was suppressed by the antioxidant N-acetylcysteine (NAC)
Noonan et al., Recent Results Cancer Res 2007 (Cell Transformation, Neoplastic...) : NAC and the flavonoids all suppressed the IkB/NF-kappaB signaling pathway even in the presence of NF-kappaB stimulation by TNFalpha, and showed reduced expression of many NF-kappaB target genes
Li et al., J Huazhong Univ Sci Technolog Med Sci 2006 : NF-kappaB activity induced by TNF-alpha was significantly increased in AM from patients with COPD, and pyrrolidine dithiocarbamate ( PDTC ) and N-acetyl-L-cysteine (NAC) significantly inhibited the activation of NF-kappaB induced by TNF-alpha ( P < 0.05 )
Yang et al., Free Radic Biol Med 2007 (Melanoma...) : In contrast, NAC inhibits NF-kappaB activation by reducing inhibitor of kappaB kinase (IKK) activity
Martinez-Losa et al., Eur Respir J 2007 : The increase in eosinophil NF-kappaB binding activity induced by GM-CSF and TNF-alpha was suppressed by NAC
Poitevin et al., Journal of thrombosis and haemostasis : JTH 2008 : PDTC and NAC inhibited NF-kappaB activation during monocyte interaction with collagen I
Jiang et al., Sichuan Da Xue Xue Bao Yi Xue Ban 2008 : To investigate the effects of N-acetylcysteine ( NAC ) on the expression of IL-8 and the activity of NF-kappaB , which are induced by lipopolysaccharide (LPS) in human uterine smooth cell ... NAC may inhibit the induction IL-8 gene and protein by LPS inhibiting NF-kappaB activation in human uterine smooth cell
Liu et al., Mol Immunol 2008 : In this study, we investigated the effect of NAC on NF-kappaB activation ... In HeLa cells, Hep3B cells, and A549 cells, DNA binding activity of NF-kappaB was induced by NAC without any other stimulation but not by tetramethylthiourea ( TMTU ) or vitamin C, suggesting that ROS is not involved in the effect of NAC ... The NAC induced DNA binding activity of NF-kappaB and phosphorylation of p65 were sensitive to a phosphatidylinositol (PI) 3-kinase inhibitor, partially sensitive to an IkappaB kinase (IKK) inhibitor, but not sensitive to a Bruton's tyrosine kinase (Btk) inhibitor
Tozawa et al., Int J Urol 2008 : Furthermore, we investigated the inhibitory effect of N-acetyl-L-cysteine (NAC) on NF-kappaB activation in the human renal tubular cell line
Eberlein et al., Journal of inflammation (London, England) 2008 : Mechanistically, NAC and DMSO inhibit HA induced gene expression by inhibiting NF-kappaB activation, but NAC had no influence on HA-fragment-AP-1 mediated gene expression
Liu et al., Regul Pept 2009 : Furthermore, we observed that NAC also inhibited UVB induced activation of NF-kappaB/p65 through decreasing the degradation and phosphorylation of IkappaBalpha
Mihm et al., AIDS 1991 : Cysteine and NAC also inhibit NF-kappa B activity as determined by electrophoretic mobility shift assays and chloramphenicol acetyl-transferase (CAT) gene expression under control of NF-kappa B binding sites in uninfected cells
Guo et al., Int J Exp Pathol 2009 (Reperfusion Injury) : From day 3 to day 6 after reperfusion, the accumulation of CSCs was significantly elevated in the injured area, which was matched with the increased SCF expression during I/R. Pretreatment of rats with NF-kappaB inhibitor, N-acetyl-L-cysteine (NAC) not only suppressed NF-kappaB activation induced by I/R but also attenuated SCF expression
Xue et al., Cardiovasc Res 2010 (Hyperglycemia) : Also, NAC and NF-kappaB inhibitors can effectively block the high glucose induced activity of NF-kappaB binding to DNA and/or peroxide production
Usui et al., J Pharmacol Sci 2010 (Atherosclerosis) : NAC inhibited TNF induced phosphorylation of JNK and p38 but not NF-kappaB
Schreck et al., EMBO J 1991 : N-acetyl-L-cysteine (NAC) , a well characterized antioxidant which counteracts the effects of reactive oxygen intermediates ( ROI ) in living cells, prevented the activation of NF-kappa B by H2O2
Talbot et al., Journal of neuroinflammation 2012 : NAC ( 1 g/kg/d x 7 days ) prevented B(1)R up-regulation, superoxide anion production and NF-kB activation induced by capsaicin ( 15 mg/kg )
Das et al., Am J Physiol 1995 : NAC , DTT, and 2-ME each activated the transcription factor NF-kappa B and increased steady-state levels of MnSOD mRNA and enzyme activity in these cells
Staal et al., AIDS Res Hum Retroviruses 1993 : We show ( 1 ) that N-acetyl-L-cysteine (NAC) , an antioxidant and an efficient glutathione ( GSH ) precursor, inhibits NF-kappa B activation and HIV expression under conditions in which GSH is depleted and NAC can not be converted to GSH, ( 2 ) that the D-stereoisomer of NAC and a wide variety of chemically unrelated antioxidants also inhibit NF-kappa B activation and/or transcription directed by the HIV LTR, and ( 3 ) that depletion of GSH, the principal intracellular antioxidant, augments HIV production in an acute infection model
Yanagihara et al., J Allergy Clin Immunol 1996 : n-Acetyl-L-cysteine (NAC) , a potent antioxidant, blocked NF-kappa B activation caused by IL-4 and by anti-CD40 mAb
Yanagihara et al., Cell Immunol 1997 (Burkitt Lymphoma) : In addition, N-acetyl-L-cysteine (NAC) , a potent antioxidant, decreased NF-kappa B activation caused by IL-4, anti-CD40 mAb, or their combination
Faruqi et al., Am J Physiol 1997 : Although NAC reduced nuclear factor-kappa B (NF-kappa B) activation in EC as measured by gel-shift assays using an oligonucleotide probe corresponding to the consensus NF-kappa B binding sites of the VCAM-1 gene ( VCAM-NF-kappa B ), the antioxidant had no appreciable effect when an oligomer corresponding to the consensus NF-kappa B binding site of the E-selectin gene ( E-selectin-NF-kappa B ) was used
Pahan et al., Free Radic Biol Med 1998 : Since activation of NF-kappaB is necessary for the induction of iNOS, we examined the effect of NAC on the activation of NF-kappaB
Bellezzo et al., J Lab Clin Med 1998 (Liver Diseases) : LPS activated NF-kappaB in Kupffer cells, and this response was inhibited by NAC and alpha-TOC
Gukovsky et al., Am J Physiol 1998 (Pancreatitis) : Antioxidant N-acetylcysteine (NAC) blocked NF-kappaB activation and significantly improved parameters of pancreatitis
Biagioli et al., Free Radic Biol Med 1999 : Despite the effects of NAC on IL-8 elaboration and NF-kappaB activation, RV stimulated increases in supernatant H2O2 were not altered by NAC
Tsuji et al., Clin Exp Immunol 1999 (Arthritis, Experimental) : Bucillamine and NAC inhibited NF-kappaB activation and tumour necrosis factor-alpha (TNF-alpha) mRNA expression in human monocytic leukaemia cell line THP-1, and cytokine production from monocyte cell lines at concentrations > 10-3 M