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APC — NFKB1

Text-mined interactions from Literome

White et al., Br J Haematol 2000 (Translocation, Genetic) : We assessed the effect of APC on LPS induced tumour necrosis factor alpha (TNF-alpha) production and on the activation of the central proinflammatory transcription factor nuclear factor-kappaB (NF-kappaB) in a THP-1 cell line ... APC also inhibited LPS induced activation of NF-kappaB , with APC ( 200 microg/ml ) abolishing the effect of LPS ( 100 ng/ml ) ... The ability of APC to inhibit LPS induced translocation of NF-kappaB is likely to be a significant event given the critical role of the latter in the host inflammatory response
Takehana et al., Biochem Biophys Res Commun 2002 : Despite having a strong inhibitory effect on the NF-kappaB dependent transcriptional activation, APC0576 does not inhibit the IL-1 induced DNA binding of NF-kappaB , degradation of I-kappaB-alpha, or phosphorylation of RelA ( p65 )
Yuksel et al., Thromb Haemost 2002 (MAP Kinase Signaling System...) : APC inhibited both the binding of nuclear factor-kappa B (NF-kappa B) to target sites and the degradation of I kappa B alpha ... These observations strongly suggest that APC inhibited LPS induced TNF-alpha production by inhibiting the activation of both NF-kappa B and AP-1 and that the inhibitory activity of APC might depend on its serine protease activity
Deng et al., Mol Carcinog 2004 : In this study, we investigated whether GSK-3beta/APC might regulate NF-kappaB activity through beta-catenin
Zhong et al., Anesthesiology 2004 (Myocardial Infarction...) : APC with sevoflurane attenuated NF-kappaB activation and reduced the expression of tumor necrosis factor alpha, interleukin 1, intercellular adhesion molecule 1, and inducible nitric oxide synthase
Xue et al., Exp Cell Res 2004 : APC also significantly increased the production of IL-6 and IL-8 and suppressed calcium- and LPS stimulated NF-kappaB activity
Okajima et al., Curr Vasc Pharmacol 2004 (Hypotension...) : APC inhibits ET-induced TNF-alpha production in vitro in human monocytes by inhibiting activation of NFkappaB and AP-1 by inhibiting degradation of IkappaB and mitogen activated protein kinase pathways, respectively
Yamaji et al., Thromb Res 2005 : APC in the range of 10-50 microg/mL could reduce lipopolysaccharide (LPS) induced ROS generation, nuclear factor kappaB (NF-kappaB) activation and resultant proinflammatory cytokine production
Xue et al., Ann Rheum Dis 2007 (Activated Protein C Resistance...) : APC also completely suppressed LPS stimulated NF-kappaB activation and attenuated TNF-alpha protein by more than 40 % in RA monocytes
Xue et al., Arthritis Rheum 2007 (Arthritis, Rheumatoid...) : Furthermore, APC directly suppressed the production of tumor necrosis factor (TNF) and the activation of NF-kappaB and MAP kinase p38, and inhibitors of NF-kappaB or p38 reduced the production of MMP-9, suggesting that APC inhibits MMP-9 by blocking TNF, NF-kappaB, and p38
Menschikowski et al., Thromb Res 2008 (Inflammation) : At the same time, APC increased the phosphorylation of ERK 1/2 and decreased NF-kappaB and C/EBP-beta DNA binding activities in these cells, as compared with respective stimulated controls
Lu et al., Am J Physiol Heart Circ Physiol 2009 (Myocardial Reperfusion Injury) : APC resulted in ROS dependent phosphorylation of IkappaBalpha and activation of NF-kappaB before I/R. APC also increased the expression of Bcl-2 before I/R ... ROS dependent activation of NF-kappaB by APC before I/R is a critical element in the protective effect of APC
Gramling et al., Exp Cell Res 2010 (Breast Neoplasms...) : Intracellularly, APC activates ERK, Akt, and NFkappaB , but not the JNK pathway to promote MDA-MB-231 cell motility
Gorbacheva et al., Neuroscience 2010 : The blocking effect of APC on NF-kappaB p65 translocation was observed at 1 and 4 h after treatment of neurons with glutamate, when the NF-kappaBp 65 level in the nucleus was significantly above the basal level ... Then we investigated whether the binding of APC to EPCR/PAR-1 is required to control NF-kappaB activation
Wang et al., Front Biosci (Elite Ed) 2011 (Brain Ischemia) : APC with sevofurane markedly improved neurological performance of stroke rats, significantly decreased infarct volume, and robustly suppressed activation of NF-kappa B and p38 MAPK, and expression of inflammatory cytokines