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IRAK4 — TRAF6

Pathways - manually collected, often from reviews:

• KEGG Toll-like receptor signaling pathway: Complex of IRAK1-IRAK4 → TRAF6 (protein-protein, activation)
• KEGG Toll-like receptor signaling pathway: IRAK4 → TRAF6 (protein-protein, binding/association)
• KEGG Neurotrophin signaling pathway: Complex of IRAK1-IRAK2-IRAK3-IRAK4-TRAF6 → IKBKB (protein-protein, activation)
• KEGG Leishmaniasis: IRAK1/IRAK4 → TRAF6 (protein-protein, activation)
• KEGG Chagas disease (American trypanosomiasis): IRAK1/IRAK4 → TRAF6 (protein-protein, activation)
• KEGG Toxoplasmosis: IRAK1/IRAK4 → TRAF6 (protein-protein, activation)
• KEGG Measles: IRAK1/IRAK4 → TRAF6 (protein-protein, activation)
• NCI Pathway Database IL1-mediated signaling events: TRAF6 (TRAF6) → IL1 alpha/IL1R1/IL1RAP/MYD88/IRAK4/TOLLIP complex (IL1A-IL1R1-IL1RAP-MYD88-IRAK4-TOLLIP) (modification, collaborate)
  Jiang et al., Mol Cell Biol 2002, Cao et al., Nature 1996
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL1-mediated signaling events: TRAF6 (TRAF6) → IL1 alpha/IL1R1/IL1RAP/MYD88/IRAK4/IRAK/TOLLIP complex (IL1A-IL1R1-IL1RAP-MYD88-IRAK4-IRAK1-TOLLIP) (modification, collaborate)
  Jiang et al., Mol Cell Biol 2002, Cao et al., Nature 1996
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL1-mediated signaling events: IL1 alpha/IL1R1/IL1RAP/MYD88/IRAK4/TOLLIP complex (IL1A-IL1R1-IL1RAP-MYD88-IRAK4-TOLLIP) → IRAK/TRAF6 complex (IRAK1-TRAF6) (modification, collaborate)
  Jiang et al., Mol Cell Biol 2002, Cao et al., Nature 1996
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL1-mediated signaling events: IL1 alpha/IL1R1/IL1RAP/MYD88/IRAK4/IRAK/TOLLIP complex (IL1A-IL1R1-IL1RAP-MYD88-IRAK4-IRAK1-TOLLIP) → IRAK/TRAF6 complex (IRAK1-TRAF6) (modification, collaborate)
  Jiang et al., Mol Cell Biol 2002, Cao et al., Nature 1996
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL1-mediated signaling events: IL1 beta fragment/IL1R1/IL1RAP/MYD88/IRAK4/IRAK/TOLLIP complex (IL1B-IL1R1-IL1RAP-MYD88-IRAK4-IRAK1-TOLLIP) → TRAF6 (TRAF6) (modification, collaborate) Li et al., Proc Natl Acad Sci U S A 2001, Jiang et al., Mol Cell Biol 2002, Cao et al., Nature 1996
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL1-mediated signaling events: IL1 beta fragment/IL1R1/IL1RAP/MYD88/IRAK4/IRAK/TOLLIP complex (IL1B-IL1R1-IL1RAP-MYD88-IRAK4-IRAK1-TOLLIP) → IRAK/TRAF6 complex (IRAK1-TRAF6) (modification, collaborate)
  Li et al., Proc Natl Acad Sci U S A 2001, Jiang et al., Mol Cell Biol 2002, Cao et al., Nature 1996
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL1-mediated signaling events: TRAF6 (TRAF6) → IL1 beta fragment/IL1R1/IL1RAP/MYD88/IRAK4/TOLLIP complex (IL1B-IL1R1-IL1RAP-MYD88-IRAK4-TOLLIP) (modification, collaborate)
  Li et al., Proc Natl Acad Sci U S A 2001, Jiang et al., Mol Cell Biol 2002, Cao et al., Nature 1996
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL1-mediated signaling events: IRAK/TRAF6 complex (IRAK1-TRAF6) → IL1 beta fragment/IL1R1/IL1RAP/MYD88/IRAK4/TOLLIP complex (IL1B-IL1R1-IL1RAP-MYD88-IRAK4-TOLLIP) (modification, collaborate)
  Li et al., Proc Natl Acad Sci U S A 2001, Jiang et al., Mol Cell Biol 2002, Cao et al., Nature 1996
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL1-mediated signaling events: TRAF6 (TRAF6) → IL1 beta fragment/IL1R1/IL1RAP/TICAM2/IRAK4 complex (IL1B-IL1R1-IL1RAP-TICAM2-IRAK4) (modification, collaborate)
  Bin et al., J Biol Chem 2003
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL1-mediated signaling events: IL1 beta fragment/IL1R1/IL1RAP/TICAM2/IRAK4 complex (IL1B-IL1R1-IL1RAP-TICAM2-IRAK4) → IRAK/TRAF6 complex (IRAK1-TRAF6) (modification, activates)
  Bin et al., J Biol Chem 2003
  Evidence: mutant phenotype, physical interaction
• Reactome Reaction: TRAF6 → IRAK4 (indirect_complex) Ross et al., J Biol Chem 2002, Ye et al., Nature 2002, Muroi et al., J Leukoc Biol 2008, Cao et al., Nature 1996
• Reactome Reaction: TRAF6 → IRAK4 (reaction) Ross et al., J Biol Chem 2002, Ye et al., Nature 2002, Kollewe et al., J Biol Chem 2004, Kawai et al., Nat Immunol 2004, Gottipati et al., Cell Signal 2008, Muroi et al., J Leukoc Biol 2008, Ning et al., Mol Cell Biol 2008, Cao et al., Nature 1996
• WikiPathways Regulation of toll-like receptor signaling pathway: IRAK4 → TRAF6 (activation)
• WikiPathways Regulation of toll-like receptor signaling pathway: IRAK4 → TRAF6 (activation)
• WikiPathways Structural Pathway of Interleukin 1 (IL-1): IRAK4 → TRAF6 (unknown)
• WikiPathways TLR4 Signaling and Tolerance: Complex of IRAK1-MYD88-IRAK4 → TRAF6 (activation)
• WikiPathways Toll-like Receptor Signaling Pathway: IRAK4 → TRAF6 (activation)
• WikiPathways Toll-like Receptor Signaling Pathway: IRAK4 → TRAF6 (activation)
• WikiPathways Toll-like Receptor Signaling: Complex of IRAK4-IRAK1 → TRAF6 (activation)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: TRAF6 — IRAK4 (physical association, affinity chromatography technology) Zhang et al., Cell Res 2013*
• IRef Biogrid Interaction: TRAF6 — IRAK4 (physical association, affinity chromatography technology) Li et al., Proc Natl Acad Sci U S A 2002
• IRef Hprd Interaction: TRAF6 — IRAK4 (in vivo) Li et al., Proc Natl Acad Sci U S A 2002
• IRef Hprd Interaction: TRAF6 — IRAK4 (in vitro) Li et al., Proc Natl Acad Sci U S A 2002
• IRef Innatedb Interaction: IRAK4 — TRAF6 (unknown, -) Li et al., Proc Natl Acad Sci U S A 2002
• IRef Intact Interaction: Complex of IRAK4-TRAF6-PELI1-IRAK1 (association, anti tag coimmunoprecipitation) Jiang et al., J Biol Chem 2003
• IRef Ophid Interaction: IRAK4 — TRAF6 (aggregation, confirmational text mining) Li et al., Proc Natl Acad Sci U S A 2002
• IRef Ophid Interaction: IRAK4 — TRAF6 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Qian et al., J Biol Chem 2001 : IRAK mediated translocation of TRAF6 and TAB2 in the interleukin-1 induced activation of NFkappa B
Peng et al., Ann N Y Acad Sci 2007 : Further, TRAF6 is involved in the activation of JNK and IRAK4 is involved for the activation of IKK and PKCzeta in a Talpha1 induced system